感觉统合训练对MCI患者语义理解N400的影响  

The Impact of Sensory Integration Training on the MCI Patients Semantic Understanding by Event-related Potential N400

作　　者：李秀艳[1] 王爱华[1] 刘霞[2] 孙延超[1] 杨海英[1] 许桂春[1] 王烁[1] 苏萌萌[1] 魏秀红[1] 

机构地区：[1]潍坊医学院护理学院,山东潍坊261053 [2]潍坊医学院附属医院手术室

出　　处：《潍坊医学院学报》2012年第1期1-4,共4页Acta Academiae Medicinae Weifang

基　　金：国家自然科学基金资助课题（课题编号：81041117）;山东省自然基金资助课题（课题编号：ZR2011HM002）

摘　　要：目的 探讨感觉统合训练对MCI患者语义理解力N400的影响.方法 研究采用配对设计,从潍坊某老年苑500例老年人中用MMSE量表筛选出了32例MCI患者,随机分为观察组（n=16）和对照组（n=16）,观察组给予感觉统合训练,对照组不给予任何干预,干预时间为2个月.采用美国Neuroscan公司生产的ERP系统,用STIM2软件编写刺激程序（语义违例实验）,用SCAN 4.3软件记录并分析数据,应用SPSS17.0进行t检验分析结果.结果 ①两组均产生较明显的特异性成分N400;②与对照组相比,观察组反应时明显缩短,正确率明显提高,差别有统计学意义（P〈0.05）;取Fz,Cz,Pz,C3,C4五电极潜伏期平均值,与对照组相比,观察组潜伏期缩短（P〈0.05）,波幅明显增大（P〈0.01）.结论 感觉统合训练能够改善MCI患者的语义理解能力.Objective To study the impact of Sensory integration training on the MCI patients semantic understanding by Eventrelated Potential N400. Methods Thirty-two patients with MCI were screened from 500 ehlerly people who were in aged Court in Weifang by MMSE scale,those patients were divided into the observation group（n = 16） and the control group（ n = 16）, observation group were given Sensory integration training while without any treatment in control group. There was 2 months about intervention time. Stimulation procedures （ semantic violation experiment） were written by STIM2 software with /IS Neuroscan ERP system. The SCAN 4.3 software was used to record and analyze data,apply SPSS 17.0 was used to do T-test. Results （1）Both groups have an obvious specific component N400. （2）Compared with the control group,the observation group reaction time was significantly shorter,the correct rate rises apparently （P 〈 0.05 ） ;With Fz ,Cz, Pz, C3, C4 five electrode lateney were averaged,the latency of the observation group was shortened compared with the control group（ P 〈 0.05 ） ,and amplitude increased significantly （ P 〈 0.01 ）. Conclusion Sensory integration training can improve the semantic understanding of MCI patients.

关 键 词：感觉统合训练 轻度认知障碍 事件相关电位 N400 

分 类 号：R395[哲学宗教—心理学]