轻度认知障碍和常态老人1H-MRS的对照研究  

The Study of Proton Magnetic Resonance Spectroscopy in Mild Cognitive Impairment and Normal Old People

作　　者：李丽新[1,2] 刘利静[1,2] 李秀艳[3] 魏秀红[3] 王珊珊[3] 巩平[1,2] 

机构地区：[1]潍坊医学院医学影像学系,山东潍坊261053 [2]潍坊医学院附属医院影像中心 [3]潍坊医学院护理学院

出　　处：《潍坊医学院学报》2012年第1期8-10,共3页Acta Academiae Medicinae Weifang

基　　金：国家自然科学基金资助课题（课题编号：81041117）

摘　　要：目的 探讨轻度认知障碍海马区域氢质子磁共振波谱的特点,明确其对轻度认知障碍的诊断价值.方法 对15例轻度认知障碍患者（轻度认知障碍组）和15例正常老年人（正常对照组）的海马区域行氢质子磁共振波谱成像,采用配套软件对图像处理,分析后得到N-乙酰天门冬氨酸/肌酸、胆碱/肌酸、肌醇/肌酸的值,并进行比较.结果 与正常对照组相比,轻度认知障碍组的N-乙酰天门冬氨酸/肌酸水平显著降低（P〈0.05）,而肌醇/肌酸水平增高（P〈0.05）,轻度认知障碍组和正常对照组的胆碱/肌酸水平无显著差异（P〉0.05）.结论 氢质子磁共振波谱能敏感地监测脑内代谢产物的变化,可对轻度认知障碍做出较早及较准确的诊断,是轻度认知障碍诊断的重要方法.Objective To evaluate the characteristic of the proton magnetic resonance spectroscopy（IH-MRS） at hippocampus in mild cognitive impairment（MCI） and normal ohl people,and identify the value of I H-MRS for diagnosing the MC1. Methods Fifteen MCI patients（ MCI group） and fifteen normal oh] people（ NC group） were scanned by 1 H-MRS techniques at hippocampal. Then, I H-MRS images of the two groups were processed and analyzed with the software equipped. The numbers of NAA/Cr,Cho/Cr and ml/Cr were obtained and compared. Results The level of NAA/Cr of MCI group was lower but the ml/Cr was higher with significant difference（ P 〈 0.05 ） comparing with the NC group. There was no significant change in Cho/Cr between the MCI and the NC group（ P 〉 0.05 ）. Conclusion 1 H-MRS can monitor the diversity of the brain metabolile suseeptively and make an earlier and preciser diagnosis for the MCI. So 1 H-MRS is an important method for diagnosing the MCI.

关 键 词：轻度认知障碍 氢质子磁共振波谱 海马 

分 类 号：R445.2[医药卫生—影像医学与核医学]