鱼类Ghrelin的研究进展  

Research Progress of Fish Ghrelin

作　　者：尹传龙[1] 张昊星[1] 彭焕文[1] 杨雁[1] 李艳利[1] 马亮波[2] 

机构地区：[1]西南大学生命科学学院淡水鱼类资源与生殖发育教育部重点实验室,重庆400715 [2]重庆大学化学化工学院新型微纳器件与系统技术国防重点学科实验室,重庆400030

出　　处：《安徽农业科学》2012年第10期5962-5965,共4页Journal of Anhui Agricultural Sciences

基　　金：重庆市自然科学基金(NO CSTC2008BB1098)资助

摘　　要：Ghelin是1条N末端第3个氨基酸被脂肪酸链修饰含有28个氨基酸的多肽。Ghrelin的发现扩展了其在脊椎动物调节能量动态平衡中的作用。Ghrelin不仅具有刺激鱼类生长激素的释放、提高摄食量和引起肥胖等生物作用,还能影响多种激素释放以及调节GH/IGF-1轴。其生物学作用主要通过与体内的内源性配体生长激素促分泌素受体-1a(GHSR-1a)结合而实现。针对以上这些重要的生物学作用,介绍了鱼类Ghrelin的研究进展。Ghrelin is a 28 amino acid peptide with a fatty acid chain modification on the N-terminal third amino acid.The discovery of Ghrelin has broadened our understanding of the regulation of energy homeostasis in vertebrates.It was shown that Ghrelin was related to a series of biological functions and effects including stimulating GH release,promoting food intake and adiposity,it also influenced many other hormone release and regulated GH/IGFF-1 axis.The biological functions of Ghrelin were achieved through binding with the growth hormone（GH） of secretagogue receptor-1a（GHSR-1a）.According to these important biological functions,the research progress of Ghrelin was reviewed.

关 键 词：GHRELIN 摄食 鱼 

分 类 号：S912[农业科学—水产科学]