桑叶多糖对2型糖尿病大鼠GLUT4 mRNA表达的影响  

Effect of Mulberry Leaves Polysaccharides on Insulin Resistance and Gene Expression of GLUT4 in Type 2 Diabetes Mellitus Rats

作　　者：刘洪凤[1] 韩智学[1] 赵正林[1] 王桂云[1] 田丽梅[1] 

机构地区：[1]牡丹江医学院生物化学教研室,黑龙江牡丹江157011

出　　处：《中国食物与营养》2012年第3期68-69,共2页Food and Nutrition in China

基　　金：黑龙江省牡丹江市科学技术计划研究项目(项目编号:Z2011s002)

摘　　要：目的:探讨桑叶多糖(Mulberry Leaves Polysaccharides,MLP)对2型糖尿病(2-DM)大鼠脂肪组织葡萄糖转运蛋白4(GLUT4)基因表达的影响。方法:将Wistar大鼠随机分为正常对照组、模型组、桑叶多糖高、中、低剂量治疗组。用药12周后,RT-PCR检测GLUT4 mRNA基因表达水平。结果:桑叶多糖高、中、低剂量治疗组GLUT4 mRNA表达高于模型组。结论:桑叶多糖可上调2型糖尿病大鼠GLUT4 mRNA表达,从而实现其降血糖作用。[Objective] To investigate the effect of mulberry leaves polysaccharides （MLP） on insulin resistance and the expression of GLUT4 mRNA of rats with type 2 diabetes. [Method] The rats model with type 2 diabetes were induced by high calorie feeding and small dose injection of STZ. Wistar rats were randomly divided into the control group, model group and high, middle, low doses of MLP groups. The mRNA expression of GLUT4 was metered by RT-PCR at the end of 12 weeks. [Result] The mRNA expression of GLUT4 gene in- creased in the high, middle and low doses of MLP groups. [Conclusion] MLP could decrease insulin resistance by increasing mRNA expres- sion of GLUT4 gene in 2-DM rats.

关 键 词：桑叶多糖 2型糖尿病 胰岛素抵抗 葡萄糖转运蛋白4 

分 类 号：R285.5[医药卫生—中药学]