熊去氧胆酸关键中间体的合成工艺研究  

Synthesis of a key intermediate for ursodeoxycholic acid

作　　者：朱颖熹[1] 李杰[1] 吴勇[1] 海俐[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《化学试剂》2012年第4期366-368,共3页Chemical Reagents

摘　　要：优化熊去氧胆酸中间体的合成工艺,提高反应收率,摸索反应条件及重结晶等,总收率达到43.0%。目标化合物结构经熔点、1HNMR谱、13CNMR谱和MS得到确证。改进后的合成工艺切实可行,适合工业化生产。To optimize the synthetic process of an intermediate for Ursodeoxycholic,and to increase the yield. Grope for reac- tion conditions and recrystallization. The improved synthetic method is more economical and effective for large-scale manu- factory and the overall yield reached to 43.0%. The structure of target compound was identified by melting point, ^1HNMR, ^13CNMR and MS. The improved synthetic process is practica- ble and suitable for large-scale manufacture.

关 键 词：熊去氧胆酸 Δ4-3-酮胆烷酸甲酯 工艺研究 

分 类 号：O629.22[理学—有机化学]