兔膝关节腔内注射黄原胶的安全性评价  

Safety evaluation of intra-articular injection of xanthan gum into knee joint of rabbit

作　　者：韩冠英[1,2,3] 凌沛学[1,2] 王凤山[1] 王桂兰[1,2] 邵华荣[1,2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东省生物药物研究院博士后科研工作站,山东济南250101 [3]辽宁医学院药学院,辽宁锦州121001

出　　处：《中国生化药物杂志》2012年第2期109-112,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金："泰山学者"建设工程专项经费资助

摘　　要：目的评价兔膝关节腔注射黄原胶的安全性。方法在兔膝关节腔分别注射2%,1%和0.5%的黄原胶注射液和生理盐水0.1 mL/kg,每周1次,连续5周。检测兔膝关节宽度、血液学和血液生化参数并观察肝、肾、膝关节组织病理学变化。结果与生理盐水组比,不同剂量黄原胶组膝关节宽度、血液学及血液生化参数等均无明显改变;肝、肾及关节组织未见明显病理改变。结论在兔膝关节腔注射黄原胶(0.5%～2%)0.1 mL/kg,每周1次,连续5周,全身及局部未见明显毒性作用。Purpose To evaluate the safety of intra-articular injection of xanthan gum（XG） into knee joint of rabbit.MethodsRabbits were intra-articularly injected with 0.5%,1%,2%XG or 0.9% NaCl injection 0.1 mL/kg in knee joints once a week for 5 weeks.The width of knee joint,hematological and biochemical parameters were examined before and after treatment.The histopathological changes in liver,kidney and knee joint were observed.ResultsCompared with normal saline group,the width of knee joint,hematological and biochemical parameters showed no significant change in XG group by using different doses,and no obvious histopathological changes were detected in liver,kidney and knee joint.ConclusionWhen intra-articularly injected with 0.5%-2% XG 0.1 mL/kg in rabbit knee joint once a week for 5 weeks,there is no significant system and topical toxicity.

关 键 词：黄原胶 兔膝关节腔 注射 安全性 

分 类 号：R965.3[医药卫生—药理学]