遍地金不同提取物的抗抑郁作用  

Study on antidepressant activity of different extracts from Hypericum wightianum

作　　者：石金城[1] 孙兴华[2] 刘媛[1] 夏超[1] 林本青[2] 樊明[2] 张桂森[3] 张惠云[4] 

机构地区：[1]南京工业大学江苏省药物研究所有限公司,江苏南京210009 [2]南京工业大学,江苏南京210009 [3]江苏恩华药业股份有限公司,江苏徐州221002 [4]山东中医药大学实验动物中心,山东济南250355

出　　处：《华西药学杂志》2012年第2期128-131,共4页West China Journal of Pharmaceutical Sciences

基　　金：产学研联合创新资金--前瞻性联合研究项目:天然产物抗抑郁症创新药物的探索性研究(项目编号:BY2010103)

摘　　要：目的筛选遍地金提取物的抗抑郁活性组分,并初步了解各活性组分的抗抑郁作用机制。方法将遍地金提取物分为3个不同的组分,应用6种抗抑郁药理模型筛选抗抑郁活性组分。结果提取物中所有组分的中、小剂量均可显著增加大鼠成功逃避次数,大剂量均可显著减少小鼠的游泳不动时间;水、正丁醇提取组分各个剂量均可显著减少小鼠的悬尾不动时间。但5-HTP致小鼠甩头行为实验中,各组分无显著性差异;利血平及阿朴吗啡引起的体温降低试验中,各组分也无显著性差异。结论遍地金的水、正丁醇提取组分均有较好的抗抑郁作用,水提取组分的效果最佳,正丁醇提取组分次之。OBJECTIVE To screen the antidepressant extracts of Hypericum wightianum and preliminarily investigate its mechanism of antidepressant.METHODS Extracts of Hypericum wightianum was divided into three different fractions,whose activity was evaluated by six antidepressant pharmacological models.RESULTS The medium and small dose groups of all extracts could significantly increase the escapable times of mice.The big dose group of all extracts could significantly shorten the immobility time of mice in swimming test.Each dose group of water and n-butanol extracts could shorten the immobility time of mice in the tail suspension test.While the test of the head twitches of mice induced by 5-HTP showed no significant difference among all fractions,and the test of the declining body temperature induced by Reserpine and Emetomorphine in mice also shows no significant difference among all extracts.CONCLUSION Water and n-butanol extracts of Hypericum wightianum have shown remarkable antidepressant activity,with water extracts better than n-butanol extracts.

关 键 词：遍地金 抗抑郁 药效学筛选 

分 类 号：R96[医药卫生—药理学]