碳糊电极法测定美托洛尔片中的美托洛尔  

Determination of Metoprolol tablets by carbon paste electrode

作　　者：李东辉[1] 李潇[2] 

机构地区：[1]辽宁医学院,辽宁锦州121001 [2]中国医科大学,辽宁沈阳110001

出　　处：《华西药学杂志》2012年第2期214-216,共3页West China Journal of Pharmaceutical Sciences

基　　金：辽宁省自然科学基金项目(20102137)

摘　　要：目的建立用碳糊美托洛尔电极测定美托洛尔片含量的方法。方法利用该电极对美托洛尔的响应,测定美托洛尔片的含量。结果电极的Nernst响应范围为0.01～5.0×10-6 mol.L-1,级差为30.2 mV.pC-1,检出限为3.2×10-6 mol.L-1。结论碳糊美托洛尔电极法可简便、快速、准确地检测片剂中美托洛尔的含量。OBJECTIVE To establish an accurate method to determine Metoprolol by carbon paste electrode.METHODS Metoprolol was quantitatively determined based on the Nernst response of the electrode to Metoprolol.RESULTS The electrode showed Nernst response to Metoprolol in the range of 0.01-5.0×10-6 mol·L-1 with a slope of 30.2 mV·pC-1.The detection limit was 3.2×10-6 mol·L-1.CONCLUSION The method can be used to determine the concentration of Metoprolol in the tablets simply,rapidly and accurately.

关 键 词：美托洛尔 碳糊电极 固体石蜡 测定 

分 类 号：R917[医药卫生—药物分析学]