子宫动脉栓塞术和口服达那唑治疗子宫腺肌病的临床对比分析  

Clinical Comparative Analysis of Uterine Artery Embolization and Danazuo in the Treatment of Adenomyosis

作　　者：徐文健[1] 周顺[1] 黄成义[1] 王银[1] 段小义[1] 

机构地区：[1]江苏省南京医科大学附属南京妇幼保健院,江苏南京210004

出　　处：《实用妇产科杂志》2012年第4期304-307,共4页Journal of Practical Obstetrics and Gynecology

基　　金：江苏省南京市科技局人才培养项目(编号:200905010)

摘　　要：目的:探讨行子宫动脉栓塞术和口服达那唑胶囊两种方法治疗子宫腺肌病的临床效果。方法:将我院2006年5月至2010年3月84例子宫腺肌病患者的临床资料进行回顾性分析,根据治疗方法的不同将患者分为两组,行子宫动脉栓塞术治疗的为子宫动脉栓塞组(44例),口服达那唑胶囊的为口服药物组(40例),观察2组患者治疗后3个月、6个月、1年、2年痛经变化、月经周期和量的改变、子宫体大小改变及部分患者的妊娠情况。结果:子宫动脉栓塞组术后痛经减轻、月经量明显减少和子宫体缩小情况均优于口服药物组(P<0.01,P<0.05)。子宫动脉栓塞组在随访过程中有妊娠愿望的患者妊娠率(66.7%)高于口服药物组(33.3%),而子宫动脉栓塞组肝功能损伤、闭经和术后复发的发生率(0、4.5%、6.8%)均低于口服药物组(27.5%、32.5%、67.5%),差异有统计学意义(P<0.05,P<0.01)。结论:子宫动脉栓塞术在子宫腺肌病临床治疗中疗效明显优于口服达那唑,并能够完整保留子宫,不良反应小,是值得推广的针对子宫腺肌病的微创治疗方法。Objective：To investigate the clinical effects of uterine artery embolization （UAE） and Danazuo in the treatment of symptomatic adenomyosis. Methods ：84 cases with adenomyosis in our hospital from May 2006 to March 2010 were retrospectively analyzed. All of the patients were divided to two groups according to different treatment. Group A-（44 cases） underwent UAE, Group B（40 cases）took Danazuo for three months. Changes of menorrhalgia, menstrua! cycle and amount, uterine size and pregnant status of some cases were observed 3 months, 6 months, 1 year and 2 year after treatment. Results：Alleviation of menor- rhalgia, decrease of menstrual amount and uterine size in Group A was obvious better than group B （ P 〈 0.01 or P〈O. 05. ） The pregnancy rate in Group A was higher than that in Group B（66.7% vs 33.3%）. The liver function injury, amenorrhea and recurrence rate in group A （0, 4.5%, 6. 8%） was lower than group B （27. 5%, 32.5%, 67.5% ）. There was statistical difference （ P 〈 0.05, P 〈 0. 01 ）. Conclusions： UAE is more effective than Danazuo in the treatment of Adenomyosis. It can reserve the uterus completely with less side effects, which is worth widely using in the treatment of adenomyosis.

关 键 词：子宫腺肌病 子宫动脉 栓塞 达那唑 

分 类 号：R711.71[医药卫生—妇产科学]