二甲双胍和阿卡波糖治疗早期糖尿病肾病疗效比较  

Comparison of treatment of metformin and acarbose on early diabetic nephropathy in type 2 diabetes mellitus

作　　者：肖雪娜[1] 王莹[2] 马彩娟[3] 张鸿雁[4] 郭菊秋[5] 王心捷 

机构地区：[1]河北省唐山市第三医院内分泌科,河北唐山063100 [2]河北省唐山市第三医院护理部,河北唐山063100 [3]河北省唐山市第三医院骨科,河北唐山063100 [4]河北省任丘市华北油田总医院内分泌科,河北任丘062552 [5]河北省唐山市古冶区医院,河北唐山063000 [6]河北省唐山市丰润区第二人民医院内分泌科,河北唐山064000

出　　处：《中日友好医院学报》2012年第2期86-89,共4页Journal of China-Japan Friendship Hospital

基　　金：唐山市市级科研立项课题;编号101302103c

摘　　要：目的:比较二甲双胍和阿卡波糖对早期糖尿病肾病的疗效。方法:将87例2型糖尿病早期糖尿病肾病的患者随机分为二甲双胍组和阿卡波糖组。二甲双胍组45例口服二甲双胍片,阿卡波糖组42例口服阿卡波糖片,疗程48周,观察2组治疗前后的血压(BP)、空腹血糖(FPG)、稳态模型胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbA1c)、血清高敏C反应蛋白(Hs-CRP)、尿白蛋白排泄率(UAER)的变化。结果:2组患者FPG、HbA1c均显著下降,但在降低BP、HOMA-IR、Hs-CRP、UAER方面二甲双胍组优于阿卡波糖组(P<0.05)。结论:对于2型糖尿病早期糖尿病肾病的患者,二甲双胍较阿卡波糖更有效地降低UAER。Objective：To compare the effects of metformin and acarbose on early diabetic nephropathy.Methods：Eighty seven cases of type 2 diabetic mellitus（T2DM）with early diabetic nephropathy were randomly divided into two groups,metformin group（45 cases）and acarbose group（42 cases）,treated with metformin or acarbose for 48 weeks.The parameters of two groups including blood pressure（BP）,fasting glucose（FPG）,glycosylated hemoglobin C（HbA1c）,homeostatic model assessment of insulin resistance,high sensitivity C-reactive protein（Hs-CRP）and urinary albumin excretory rate（UAER）were observed before and after therapy.Results：FPG and HbA1c were significantly declined in both groups.Compared with acarbose group,BP,HOMA-IR,Hs-CRP,UAER were significantly decreased in metformin group（P0.05）.Conclusion：For the T2DM with early diabetic nephropathy metformin reduces UAER better than acarbose.

关 键 词：二甲双胍 阿卡波糖 早期糖尿病肾病 炎症 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]