制霉菌素口腔双层贴膜的制备与质量控制  

Preparation and quality control of double-layer film of Oral Nystatin

作　　者：叶继锋[1] 侯齐书[1] 戴伟伟[1] 林奕沨[1] 

机构地区：[1]温州医学院附属第二医院,温州325035

出　　处：《海峡药学》2012年第3期18-20,共3页Strait Pharmaceutical Journal

摘　　要：目的制备制霉菌素口腔双层贴膜并建立其质量考察方法。方法采用乙基纤维素作为空白隔离层成膜材料,采用聚乙烯醇和羧甲基纤维素钠作为成膜材料制备含药膜,采用紫外分光光度法测定其中制霉菌素的含量。结果制霉菌素在1.02～20.40μg.mL-1内呈良好的线性关系(r=0.9999),平均回收率为100.12%,(RSD=0.32%,n=6)。结论该膜剂制备方法简单可行,质量可控。OBJECTIVE To prepare double-layer film of oral nystatin and to establish its quality control method.METHODS With Ethyl cellulose ethoce as a blank spacer film-forming material,Use of polyvinyl alcohol and sodium carboxymethyl cellulose as a film forming material preparation.Main drug nystatin content was determined by ultraviolet spectrophotometry.RESULTS The linear range of nystatin was 1.02~20.40μg·mL-1（r=0.9999）,the average recoveries of nystatin was 100.12%,（RSD=0.32%,n=6）.CONCLUSION The preparing method is simple,and quality control is reasonable.

关 键 词：制霉菌素 双层膜 制备工艺 质量 

分 类 号：TQ460.6[化学工程—制药化工]