复方丹参注射液联合维生素E治疗新生儿硬肿症的系统评价  

A Systematic Review of Compound Danshen Injection Combined with Vitamin E in the Treatment of Neonatal Scleredema

作　　者：赵润[1] 肖晓芸[1] 任静[1] 

机构地区：[1]绵阳市妇幼保健院,四川绵阳621000

出　　处：《中国药房》2012年第16期1501-1504,共4页China Pharmacy

摘　　要：目的:系统评价复方丹参注射液联合维生素E治疗新生儿硬肿症的临床疗效。方法:计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普(VIP)和万方数据库,PubMed和Cochrane图书馆,纳入复方丹参注射液联合维生素E治疗新生儿硬肿症的随机对照试验(RCT),对纳入研究进行Jadad质量评分,对同质性结果进行合并分析。结果:共纳入12项RCT,合计969例患者。所有文献Jadad评分均为3分。Meta分析结果显示,复方丹参注射液联合维生素E治疗新生儿硬肿症的显效率[RR=1.72,95%C(I1.38,2.15),P<0.00001]、硬肿好转时间[MD=-1.81,95%C(I-1.92,-1.70),P<0.00001]、硬肿消退时间[MD=-1.58,95%C(I-1.82,-1.33),P<0.00001]、体温恢复时间[MD=-2.40,95%C(I-3.34,-1.46),P<0.00001]及住院时间[MD=-2.95,95%CI(-3.55,-2.36),P<0.00001]与对照组比较,差异均有统计学意义。结论:在常规治疗基础上联合复方丹参注射液和维生素E治疗新生儿硬肿症疗效优于单纯常规治疗,且安全性较好。但由于本研究纳入文献质量较低,有待临床开展大样本的RCT继续研究。OBJECTIVE：To evaluate the clinical efficacy of Compound danshen injection combined with vitamin E in the treatment of neonatal scleredema.METHODS：According to evidence based medicine methods,randomized controlled trials（RCTs）were retrieved databases of CBM,CNKI,VIP,Wanfang,PubMed and the Cochrane Library.RCTs of Compound danshen injection combined with vitamin E in the treatment of neonatal scleredema were included,including studies＇quality was evaluated by Jadad method,and Meta-analysis of homogeneity study results was performed.RESULTS：A total of 12 studies involving 969 patients were gathered,all of which Jadad score was 3.Meta-analysis results indicated the difference of excellence rate[RR=1.72,95%CI（1.38,2.15）,P0.000 01],scleredema improving time[MD=-1.81,95%CI（-1.92,-1.70）,P0.000 01],scleredema regression time[MD=-1.58,95%CI（-1.82,-1.33）,P0.000 01],body temperature regression time[MD=-2.40,95%CI（-3.34,-1.46）,P0.000 01] and hospitalization time[MD=-2.95,95%CI（-3.55,-2.36）,P0.000 01] were significant between trial group and control group.CONCLUSION：Based on evidence recently,Compound danshen injection combined with vitamin E on the basis of conventional therapy is better than conventional therapy alone for neonatal scleredema.But as a result of this research inctuded studies of lower quality,to be further clinical sample RCT to continue to study.

关 键 词：复方丹参注射液 维生素E 新生儿硬肿症 META分析 系统评价 

分 类 号：R722.16[医药卫生—儿科] R985[医药卫生—临床医学]