宫颈病变患者配偶人乳头瘤病毒检测结果分析  

An analysis of the infection of human papillomavirus in the sexual partners of the patients with cervical lesions

作　　者：郑利雄[1,2] 熊峰[1,2] 张金玲[1,3] 王莉菲[1,3] 杨菊芳 谢红[1,3] 姚勇丰 杜晓红[1,2] 宋彪 马利国[1,3] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院皮肤科,广东深圳518020 [3]深圳市人民医院妇科,广东深圳518020

出　　处：《中国实用妇科与产科杂志》2012年第4期294-296,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：深圳市科技基金资助项目(200902009)

摘　　要：目的了解宫颈病变患者配偶人乳头瘤病毒(HPV)感染情况,为宫颈病变的预防提供依据。方法对2009年12月至2011年4月在深圳市人民医院妇科门诊就诊,有宫颈病变且高危型HPV检测阳性的患者共86例及健康妇女35例(其配偶分别为研究组86例和对照组35例),采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术,检测其配偶阴部HPV感染情况。结果研究组HPV检出阳性率为45.35%(39/86),明显高于正常对照组的17.14%(6/35)(P﹤0.01)。研究组HPV阳性者中有53.8%(21/39)的夫妻双方感染相同的HPV亚型,其中52型占首位。结论宫颈病变患者配偶HPV感染明显高于正常人群,且部分夫妻感染相同的HPV亚型,故对配偶进行HPV检测和健康宣教有利于宫颈病变的预防。Objective To investigate the infection of human papillomavirus （HPV） in the sexual partners of the patients with cervical lesions in order to provide the evidence for the prevention of cervical lesions. Methods 86 cases of cervical lesions infection highrisk HPV and 35 cases of health were enrolled in Gynecologic outpatient of Shenzhen People Hos pital between Dec 2009 and Apr 2011. Their sexual partner genital epithelial cells were collected and HPV DNA was detected by DNA microarray with PCR amplification in vitro combination of reverse dot blot hybridization technology. Resuits The detection rate of HPV-positive in the sexual partners of the patients with cervical lesions was 45.35% （ 39/ 86） ,significantly higher than the normal control group（17. 14,6/35） （P 〈 0. 01）. There were 53.8% （21/39）of couples with HPV-positive infection the same subtype, and HPV 52 was the most prevalent infection. Conclusion The infection rate of HPV in the sexual partners of the patients with cervical lesions was significantly higher than the normal control group. And some couples infected the same HPV subtype. Detection of HPV DNA to sexual partner and health education are conducive to the prevention of cervical lesions.

关 键 词：宫颈病变 人乳头瘤病毒 配偶 

分 类 号：R711.74[医药卫生—妇产科学]