肝硬化患者血清微量元素、免疫功能特点及相关性研究  

Characteristics of Trace Elements and Immune Function in Patients with Hepatic Cirrhosis and Correlativity Analysis

作　　者：泽塔多吉[1,2] 李晓爽[1] 吕洪敏[3] 齐玉梅[3] 肖慧娟[3] 

机构地区：[1]天津医科大学三中心临床医学院,天津市300070 [2]西藏昌都地区人民医院 [3]天津市第三中心医院

出　　处：《中国全科医学》2012年第10期1112-1114,共3页Chinese General Practice

摘　　要：目的探讨肝硬化患者血清微量元素、免疫功能特点及相互关系。方法采用微量元素检测仪检测52例肝硬化患者和30例对照者的5种血清微量元素水平;采用流式细胞术测定外周血T淋巴细胞亚群水平。结果肝硬化组血清锌(Zn)、铁(Fe)、铬(Cr)、硒(Se)水平均低于对照组,以失代偿期显著;肝硬化组血清铜(Cu)水平高于对照组,且以失代偿期明显,差异有统计学意义(P<0.05)。肝硬化组总T淋巴细胞(CD3)、辅助性T淋巴细胞(CD4)、自然杀伤细胞(NK)水平均低于对照组,以失代偿期明显,差异有统计学意义(P<0.05)。直线相关分析表明:血清Cu水平与CD3、CD4、NK呈负相关,血清Zn水平与CD3、CD4、NK呈正相关(P<0.05)。对肝硬化微量元素进行Logistic回归分析,结果显示Zn[OR=42.023,95%CI(1.164,1 516.474),P=0.041]、Cu[OR=69.429,95%CI(0.942,5 114.612),P=0.048]是肝硬化的相对危险因素。结论肝硬化时除进行常规保肝治疗外,检测和纠正血清微量元素、免疫功能等综合判断对评估肝硬化患者病情轻重及指导治疗有重要的意义。Objective To study the relationship between trace elements and immune function of patients with hepatic cirrhosis.Methods The level of the five serum trace elements in 52 patients with hepatic cirrhosis and 30 controls were detected by using Trace Element Detector,and the frequency of T-lymphocyte subsets in peripheral blood was detected by using Flow Cytometry.Results Compared with the control group,in the group of cirrhosis patients the serum Zn,Fe,Cr,Se levels were lower,and the serum Cu level was higher,especially at the decompensated stage（P〈0.05）;CD3,CD4,NK cell levels in peripheral blood were lower,especially at the decompensated stage（P〈0.05）.Linear correlation analysis showed：and CD3,CD4,NK cell levels were negatively correlated with serum Cu level,but positively correlated with serum Zn level（P〈0.05）.Logistic regression analysis showed that Zn and Cuwere the relative risk factors for cirrhosis.Conclusion Apart from conventional therapy of protecting liver function,the detection and correction serum trace elements,immune function have important positive significance for assessing the condition and treatment of patients with hepatic cirrhosis.

关 键 词：微量元素 免疫功能 肝硬化 

分 类 号：R348.5[医药卫生—基础医学] R331.15