尖紫蛤糖胺聚糖抑制肿瘤细胞生长作用的研究  

Inhibition Effect of Glycosaminoglycan from Sanguinolaria acutas on the Growth of Tumor Cells

作　　者：刘倩[1] 范秀萍[1] 吴红棉[1] 胡雪琼[1] 

机构地区：[1]广东海洋大学食品科技学院,广东湛江524025

出　　处：《现代食品科技》2012年第4期396-398,381,共4页Modern Food Science and Technology

基　　金：广东海洋大学自然科学研究项目(C1012115)

摘　　要：采用四氮唑蓝还原法(MTT法)研究了尖紫蛤糖胺聚糖对人宫颈癌细胞(Hela细胞)、人鼻咽癌细胞(CNE-2Z细胞)、慢性髓性白血病细胞(K562细胞)的体外抗肿瘤活性。结果显示:尖紫蛤糖胺聚糖对三种肿瘤细胞具有较强的抑制能力,并存在一定的量效关系;尖紫蛤糖胺聚糖与阳性药物(5-Fu)合用呈单纯相加作用或增强、协同作用。The anti-tumor effect of Glycosaminoglycan from sanguinolaria acutas on Hela cell, CNE-2Z cell and K562 cell in vitro were analyzed by MTT colorimetric method. Results showed that the GAG had anti-tumor activity and the anti-tumor effect of GAG ranged with its concentration. In synergistic inhibition effect of GAG with positive drug （5-Fu） on tumor cells have a simple addition effect or synergistic effect.

关 键 词：尖紫蛤 糖胺聚糖 抑瘤率 

分 类 号：R285[医药卫生—中药学]