组效关系中临界值的确定  

Critical Value Determination on Composition-Activity Relationship

作　　者：李顺勇[1] 宋云胜[1] 

机构地区：[1]山西大学数学科学学院,山西太原030006

出　　处：《中北大学学报（自然科学版）》2012年第1期70-72,共3页Journal of North University of China(Natural Science Edition)

基　　金：国家自然科学基金资助项目(11002083);山西省研究生教育改革项目(20102003);山西省高校高新技术产业化项目(20090006)

摘　　要：基于中药指纹图谱中的色谱峰与药效指标之间的灰色关联度,利用统计中的假设检验和非参数估计,对如何确定中药材(Traditional Chinese Medicine,TCM)中有效组分的临界值问题进行了研究.克服了主观设定临界值的缺陷,为探究中药中的有效组分提供了一种量化指标.实验结果表明:该方法能够有效地确定中药中的有效成分,验证了其可行性.Based on the gray correlation between the peaks in fingerprints and efficacy indicators of traditional Chinese medicine（TCM）,using the methods of test of hypothesis and nonparametric estimation,the determination of the critical value of active composition in TCM was investigated.The proposed method eliminates the subjectivity in the traditional process of determining the critical value of active composition in TCM.It provides a quantitative indicator for exploring the active components of TMC.Examples are proved the effectiveness and feasibility of the proposed method.

关 键 词：有效组分 关联度 临界值 非参数估计 Bootstrap重抽样 

分 类 号：O212.7[理学—概率论与数理统计]