不同证候原发性失眠症患者睡眠参数及整夜心率变化特征研究  

Characteristics of Sleep Parameters and Nocturnal Heart Rate Dynamics in Primary Insomnia Patients with Different Syndrome

作　　者：杨秀岩[1,2] 杨军[1] 黄晓洁[3] 张宏金[1] 王玲玲[3] 俞梦孙[1] 

机构地区：[1]中国人民解放军空军航空医学研究所航空医学工程研究中心,北京100142 [2]中国人民解放军第四军医大学研究生院,陕西西安710032 [3]中国人民解放军空军航空医学研究所附属医院中医科,北京100142

出　　处：《中国中医药信息杂志》2012年第4期21-24,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划(2006BAI13B06-2)

摘　　要：目的观察原发性失眠症患者的睡眠特征和睡眠期心率的变化趋势特征。方法 24例原发性失眠症患者与15例健康对照者均接受睡眠检测,观察比较3组受检者的常规睡眠参数、短觉醒指数和整夜心率变化指标的异同。结果与对照组相比,2组患者的深睡比例减少,浅睡比例增多,夜间觉醒时间增多,短觉醒指数明显增大,虚证组睡眠潜伏时间延长;2组患者睡眠期和非快速眼动(NREM)睡眠期心率变异系数增大,第1个睡眠周期平均心率/睡眠期平均心率的比值增大;第1个睡眠周期的心率变异系数增大(P<0.05)。2组之间相比,实证组短觉醒指数较大,实证组睡眠期和NREM睡眠期心率变异系数较大(P<0.05)。结论失眠症患者在常规睡眠参数、短觉醒以及心率变化趋势上均存在异常表现,其中短觉醒指数、整夜及NREM睡眠期心率变异系数可能可以作为虚实辨证的参考指标。Objective To investigate the physiological features of patients with primary insomnia during sleep.Methods Twenty-four patients were included and classified into the group with excessive syndrome and the group with deficiency syndrome,meanwhile 15 volunteers were taken as normal controls.All the subjects were undergone an nocturnal sleep examination using the micro-movement sensitive mattress sleep monitoring system.The sleep indices,arousal index and nocturnal heart rate dynamics were compared between the patients and the controls,and between the two different syndrome groups.Results As compared with the normal control,the patients in both excessive group and deficiency group presented to decrease the percentage of deep sleep,increase the percentage of shallow sleep and time of awakening and arousals.Sleep latency increased in deficiency group.The patients presented to increase the ratio of mean HR during the first sleep period to mean HR during the whole sleep,and variation coefficient of HR during sleep especially in the first sleep period（P0.05）.For the comparison of the two groups of patients,the excessive group showed higher arousal index,the excessive syndrome group showed higher variation coefficient of HR（P0.05）.Conclusion The abnormalities in sleep parameters and nocturnal HR dynamics can be taken for the objective sign of sleep quality going to bad.Arousal index and variation coefficient of HR during sleep or NREM sleep may be significative for deficiency and excess syndrome differentiation in insomnia diagnosis.

关 键 词：原发性失眠症 中医证候 睡眠参数 心率 

分 类 号：R256.23[医药卫生—中医内科学]