促性腺激素联合生长激素在超排卵治疗中的意义  

The significance of combination of gonadotropin with growth hormone in the treatment of superovulation

作　　者：夏婷婷[1,2] 徐慧灵[1] 李洁[1] 

机构地区：[1]中山大学附属第一医院生殖医学中心,广州510080 [2]中山大学附属第三医院不育与性医学科,广州510630

出　　处：《生殖医学杂志》2012年第2期119-121,共3页Journal of Reproductive Medicine

摘　　要：生长激素（GH）是一种由垂体嗜酸性细胞分泌的重要肽类激素。其基因定位于17q24．2，分子量22kDa，含有191氨基酸。分子结构与垂体催乳素（PRL）和胎盘生乳素（hPL）具有同源性。GH的合成与分泌主要受下丘脑生长激素释放激素和生长抑素的双重调节。Growth hormone could be impact follicle genesis and steroidogenesis after combined with it＇s receptor on ovarian cells directly, or through the regulation of insulin-like growth factors level. Based studies have shown that growth hormone affects the growth and development of preantral or antral follicles, promoting its＇ maturation or increasing the number of ovulation and impact of steroid hormone synthesis. The protocol of gonadotropin combined with growth hormone was reported useful in poor ovarian responder and aging women during controlled ovarian stimulation treatment in most literature. But the results are still controversial. Clarified the indication and benefits of growth hormone combined will help to improve the effective of human ovulation induction regimens.

关 键 词：卵泡生成 类固醇激素合成 生长激素 促排卵治疗 

分 类 号：R6[医药卫生—外科学]