MYH9和ABI2基因SNP在2型糖尿病人群中与血糖、胰岛素抵抗和血压的相关性  

Relationship of single nucleotide polymorphisms in MYH9 and ABI2 genes with glucose,insulin resistance,and hypertension related phenotypes in type 2 diabetes patients

作　　者：于萍[1] 蔡春友[1] 魏凤江[1] 凌超[1] 时文涛[1] 林静娜[2] 陈莉明[3] 李卫东[1] 

机构地区：[1]天津医科大学基础医学研究中心,天津300070 [2]南开大学人民医院内分泌科,天津300121 [3]天津医科大学代谢病医院肾内科,天津300070

出　　处：《天津医科大学学报》2012年第1期17-20,共4页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(81070576)

摘　　要：目的:研究MYH9和ABI2基因的单核苷酸多态性(SNP)在2型糖尿病人群中与血糖、胰岛素抵抗及高血压的关系。方法:应用基质辅助激光解吸电离飞行时间质谱技术,对773例天津地区的2型糖尿病患者的MYH9基因的8个SNP位点和ABI2基因的4个SNP位点进行基因分型,以PLINK软件进行数量性状的关联分析及基因型交互作用分析。结果:MYH9和ABI2基因SNP位点与血糖和胰岛素抵抗表型存在较广泛的关联,包括糖化血红蛋白、2 h血糖、空腹和2 h胰岛素及胰岛素抵抗指数(P<0.05)。ABI2基因SNP位点rs62183937(P=0.000),rs11675251(P=0.008)等均与血压相关。结论:MYH9和ABI2基因的多态性可能与2型糖尿病患者的血糖、胰岛素抵抗相关表型及2型糖尿病合并高血压的发病相关。Objective： To investigate the relationship of MYH9,ABI2 gene single nucleotide polymorphisms（SNPs） and glucose,insulin resistance,and hypertension in type 2 diabetes patients.Methods： Eight SNPs in MYH9 gene and 4 SNPs in ABI2 gene were genotyped in 773 type 2 diabetes patients in Tianjin area by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry（MALDITOF MS）.Plink was used for quantitative association studies and genotype interactions（epistasis） analyses.Results： Significant associations were found among MYH9 and ABI2 SNPs and insulin resistance phenotypes,including HbA1c,2-hr glucose,fasting and 2 hr plasma insulin（P0.05）.Moreover,association was found among ABI2/MYH9 SNPs and affection status of hypertension（rs62183937 and rs11675251 in ABI2,P=0.000,P=0.008,respectively）.Conclusion： It is suggested that polymorphisms in these 2 genes are associated with glucose,insulin resistance,and hypertension related phenotypes in type 2 diabetes patients.

关 键 词：胰岛素抵抗 高血压 关联分析 基因型交互作用 单核苷酸多态性 

分 类 号：R587.1[医药卫生—内分泌]