不同剂量氟伐他汀对冠心病患者瘦素、脂联素的影响  

Effect of different doses fluvastatin on leptin and adiponectin in patients with coronary heart disease

作　　者：吴艳民[1] 刘玉洁[2] 时晓迟[2] 畅晓燕[1] 赵江峰[1] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市胸科医院心内科,天津300051

出　　处：《天津医科大学学报》2012年第1期53-56,共4页Journal of Tianjin Medical University

基　　金：天津市卫生局科技基金资助项目(2011K258)

摘　　要：目的:探讨瘦素、脂联素在冠心病发病过程中的作用以及氟伐他汀用于治疗冠心病的理想剂量。方法:将住院确诊为冠心病的160例患者随机分成两组,每组80例,均在冠心病常规治疗的基础上服用氟伐他汀。第1组口服常规剂量40 mg/d,第2组口服强化剂量80 mg/d。分别于治疗前和治疗2个月后测定两组患者血清瘦素、脂联素的浓度。同时设第3组为健康对照组。结果:与治疗前相比,服用氟伐他汀2个月后,两组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)、C反应蛋白(CRP)和血清瘦素水平均明显降低(均P<0.05),高密度脂蛋白胆固醇(HDL-c)、血清脂联素水平均较治疗前明显升高(均P<0.05);与常规降脂组相比,强化降脂组TC、LDL-c下降幅度和HDL-c升高幅度更明显(均P<0.05),而TG、CRP、瘦素水平降低幅度,脂联素水平升高幅度,两组之间无较大差异(均P>0.05)。结论:血清瘦素、脂联素与冠心病密切相关。氟伐他汀可显著降低冠心病患者瘦素水平,升高脂联素水平,并且与常规降脂治疗相比,强化降脂治疗能够提供更好的保护作用。Objective： To investigate the role of leptin and adiponectin in pathogenesis of coronary heart disease（CHD） and the ideal doses of fluvastatin for treating CHD.Methods： 160 patients with CHD were randomly divided into two groups（80 cases in each group）,and all of them were taken fluvastatin on the conventional therapy of CHD.Group 1 of conventional lipid-lowering group,40 mg,daily;group 2 of intensive lipid-lowering group,80 mg,daily.The concentrations of leptin and adiponectin were detected respectively before treatment and two months after treatment.Group 3 was healthy control group.Results： Compared with before treatment,TC,TG,LDL-c,CRP and serum leptin were significantly decreased in both group 1 and 2 after two months（P0.05）,whereas HDL-c,adiponectin were significantly increased in these two groups（P0.05）.Compared with the conventional lipid-lowering group,the intensive lipid-lowering group had more lower levels of TC,LDL-c and more higher levels of HDL-c（P0.05）,although they had the same levels of TG,CRP,serum leptin and adiponectin（P0.05）.Conclusion： There is a significant association between serum leptin and adiponectin with CHD.Fluvastatin can reduce serum leptin and elevate adiponectin significantly,and intensive lipid-lowering therapy can provide better protection than conventional lipid-lowering therapy.

关 键 词：冠心病 氟伐他汀 瘦素 脂联素 

分 类 号：R541.4[医药卫生—心血管疾病]