普罗布考对不稳定性心绞痛患者PCI治疗前后vWF、sP-S和IgG-ACA的影响  

Effect of probucol on vWF, sP-S and IgG-ACA in patients with unstable angina pectoris underwent PCI

作　　者：石昭昭[1] 李广平[1] 邵帅[1] 倪艳萍[1] 刘红梅[1] 

机构地区：[1]天津医科大学第二医院心脏科,天津300211

出　　处：《天津医科大学学报》2012年第1期67-69,73,共4页Journal of Tianjin Medical University

摘　　要：目的:观察普罗布考预处理后不稳定性心绞痛(UAP)患者经皮冠状动脉介入(PCI)治疗前后血管内皮损伤指标假性血管性血友病因子(vWF),血小板活化指标sP-S(sP-S),自身免疫抗体IgG型抗心磷脂抗体(IgG-ACA)的变化。方法:100例UAP患者随机分为2组,一组患者在PCI前至少24 h接受普罗布考500 mg 2次/日和常规治疗(普罗布考组),另一组患者在PCI前只接受常规治疗(对照组)。100例患者均于PCI前即刻及术后次日采集肘静脉血用酶联免疫法检测vWF、sP-S、IgG-ACA的表达水平。结果:两组患者vWF、sP-S、IgG-ACA表达水平在PCI术前即刻均无统计学意义(P>0.05)。普罗布考组患者vWF术后次日与术前即刻相比差异无统计学意义(P>0.05);对照组患者vWF术后次日高于术前即刻(P<0.05);与对照组相比,普罗布考组患者vWF术后次日与术前即刻差值低于对照组(P<0.05)。普罗布考组患者sP-S术后次日高于术前(P<0.05),对照组患者sP-S术后次日与术前即刻相比差异无统计学意义(P>0.05);普罗布考组患者sP-S术后次日与术前即刻差值与对照组相比差异无统计学意义(P>0.05)。两组患者IgG-ACA术后次日均高于术前即刻(P>0.05);普罗布考组患者IgG-ACA术后次日与术前即刻差值与对照组相比差异无统计学意义(P>0.05)。结论:PCI治疗可以加重血管内皮损伤,激活血小板,加重免疫反应。普罗布考可以减轻因PCI造成的血管内皮损伤。Objective： To observe the effect of probucol on blood levels of von Wilebrand Factor（vWF）,souble P-selectin（sP-S） and anticardiolipin antibody of IgG type（IgG-ACA） in patients with unstable angina pectoris（UAP） underwent percutaneous coronary intervention（PCI）.Methods： 100 patients were devided into two groups,patients in probucol group accepted probucol 500 mg b.i.d.and routine treatment before PCI and patients in control group accepted routine treatment before PCI only.The expression of vWF,sP-S,IgG-ACA from brachial vein were examined at the moment before PCI and the first day after PCI using the ELISA.Results： There were no significant difference in the expression of vWF,sP-S,IgG-ACA at the moment before PCI between the two groups（P0.05）.In probucol group,the expression of vWF had no statistical difference between the moment before PCI（stage A） and that at the first day after PCI（stage B）（P0.05）.However,the expression of vWF became significantly higher in control group at stage B（P0.05）.Therefore,the difference of vWF between stage A and stage B was substantially little in probucol group compared with that in control group（P0.05）.In probucol group,the expression of sP-S became significantly higher at stage B（P0.05）.While in control group,there was no statistical difference at stage A and B（P0.05）.As a result,there was no statistical difference of sP-S（stage A and B） between the two groups（P0.05）.In both groups,the expression of IgG-ACA at stage B were significantly higher than that at stage B（P0.05）.So there was no statistical difference in IgG-ACA（stage A and stage B） between the two groups（P0.05）.Conclusion： The vascular endothelium function is impaired,platelets are obviously activated and immune reaction is accelerated in patients with UAP after PCI the first day.Probucol plays an important role in relieving the vascular endothelial injury after PCI.

关 键 词：普罗布考 不稳定性心绞痛 经皮冠状动脉介入治疗 假性血管性血友病因子 可溶性P-选择素 IgG型抗心磷脂抗体 

分 类 号：R541.4[医药卫生—心血管疾病]