间歇低氧对大鼠颏舌肌运动皮质区经颅磁刺激反应的影响  

Effects of intermittent hypoxia on the responses of genioglossus motor cortex to transcranial magneticstimulation in rats

作　　者：李婷[1] 王玮[1] 孔德磊[1] 苏皎[1] 康健[1] 

机构地区：[1]中国医科大学附属第一医院呼吸疾病研究所,沈阳110001

出　　处：《中华结核和呼吸杂志》2012年第4期283-285,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金（30871136）

摘　　要：目的应用经颅磁刺激技术探讨间歇低氧对颏舌肌运动皮质区的影响。方法选取Sprague—Dawley雄性大鼠80只按照随机数字表法分为正常对照组（10只）和间歇低氧组（各低氧组10只），应用经颅磁刺激刺激两组大鼠颏舌肌运动皮质区并记录刺激后的反应，测量并比较反应潜伏期和幅度，多组问数据比较采用单因素方差分析。结果大鼠大脑皮质前外侧区是颏舌肌运动皮质区最佳经颅磁刺激位点。与对照组[（5．20±0．64）ms，（1．21±0．53）mV]相比。间歇低氧大鼠颏舌肌运动皮质区的经颅磁刺激反应潜伏期在低氧第1天[（4．90±0．54）ms]和第14天[（4．64±1．71）ms]显著缩短，差异有统计学意义（F=3．294，P〈0．01）；反应幅度在低氧第1天[（2．28±0．57）mV]和第7天[（1．89±0．20）mV]显著增高（F=1．905，P〈0．05）。结论间歇低氧可以引起大鼠颏舌肌运动皮质区的反应性增加。Objective To explore the influence of intermittent hypoxia on the responses of genioglossus motor cortex to transcranial magnetic stimulation. Methods Male Sprague-Dawley rats were randomly divided into a control group and a chronic intermittent hypoxia group. Transcranial magnetic stimulation was applied in genioglossus motor cortex of the 2 groups. The responses of transcranial magnetic stimulation were recorded and analyzed by single factor analysis of variance. Results The anterolateral area provided an optimal motor evoked potential response to transcranial magnetic stimulation in the geuioglossus motor cortex of the rats. Genioglossus motor evoked potential latency and amplitude were significantly modified by intermittent hypoxic exposure, with a significant decrease in latency （F = 3. 294,P 〈 0. 01 ） at the I st clay [ （ 4. 90 ±0. 54） ms ] and the 14th day [ （ 4. 64 ±1.71 ） ms ], and an increase in amplitude （ F = 1. 905,P 〈0. 05） at the 1st day E （2. 28 ±0. 57）mV] and the 7th day E （ 1.89 ±0. 20）mV]. Conclusion Intermittent hypoxia could increase the transcranial magnetic stimulation response of genioglossus motor cortex in rats.

关 键 词：间歇低氧 颏舌肌 经颅磁刺激 

分 类 号：R766[医药卫生—耳鼻咽喉科]