激素补充治疗卵巢早衰的疗效观察  

Clinical observation of treating premature ovarian failure with hormone supplement therapy

作　　者：陈捷[1] 沈宇飞[1] 

机构地区：[1]江苏省南京医科大学附属南京市妇幼保健院,210004

出　　处：《白求恩军医学院学报》2012年第2期83-85,共3页Journal of Bethune Military Medical College

摘　　要：目的探讨卵巢早衰(premature ovarian failure,POF)患者性激素补充的规范治疗。方法将40例POF患者根据发病至就诊时间分为短病程组和长病程组,均接受性激素补充治疗,比较治疗前及治疗半年后更年期症状评分(Kupperman评分)、血清促卵泡刺激素(SF)水平、雌二醇(E2)水平、子宫体积、子宫内膜厚度及卵巢体积的变化情况。结果短病程组患者治疗后SF下降(P<0.01),E2升高(P<0.05);长病程组患者治疗后虽然SF有所下降,E2升高,但差异无统计学意义。两组受试患者治疗后均有规律性撤退性出血,短病程组中有1例于治疗后5个月自然妊娠,伴有低雌激素症状者均得到不同程度改善。短病程组Kupperman评分均值由治疗前29.11分降低至3.41分,长病程组Kupperman评分均值由治疗前22.17分降低至4.13分。结论早期发现POF且在闭经1年内进行激素补充治疗可以取得更好的疗效。Objective To investigate the standard method of treating premature ovarian failure with hormone supplement thera- py. Methods Forty patients who were diagnosed suffering from premature ovarian failure, according to the time from pathogenesy to diagnosis, were divided into short course group and long course group, both of which were treated with sex hormone supplement therapy （HST）. The changes of Kupperman scores,the levels of serum flitropin（SF） and estradiolum（E2）, uterine volume, endometrial thickness and ovarian volume were compared before and after 6-month treatment. Results After treatment, the concentration of SF de- creased （ P 〈 O. 01 ）, while E2 increased（ P 〈 0.05 ） in the short course group. Though the concentration of SF decreased a bit, E2 in- creased in the short course of group, there was no statistical significance. The patients in both groups had regular withdrawal bleeding after HST. 1 patient had pregnancy after 5-month treatment in the short course group. Patients accompanied with low estrogen symp- toms got improvement in different degree. The Kupperman scores in the short course group decreased from 29.11 （pretherapy） to 3.41 （ post-therapy）, while the kupperman scores in the long course group decreased from 22.17 （pretherapy） to 4.13 （post-therapy）. Con- clusion Early treating POF with HST can get better therapeutic effects.

关 键 词：卵巢早衰 血清性激素测定 性激素补充治疗 

分 类 号：R711.75[医药卫生—妇产科学]