复发性多软骨炎呼吸道受累特点的临床分析  

Clinical Analysis of the Features of Relapsing Polychondritis with Respiratory Tract involvement

作　　者：周晓明[1] 侯刚[2] 赵立[1] 

机构地区：[1]中国医科大学附属盛京医院第一呼吸内科,辽宁沈阳110004 [2]中国医科大学附属第一医院呼吸内科,辽宁沈阳110001

出　　处：《医学临床研究》2012年第3期407-410,共4页Journal of Clinical Research

摘　　要：【目的】总结和评价复发性多软骨炎（RP）呼吸道受累的特点。【方法】从临床表现、胸部影像学、肺功能检查以及支气管镜镜下表现四个方面回顾性分析RP患者呼吸道受累的特点。【结果】RP患者呼吸道受累常见，呼吸道受累的常见症状为咳嗽77．8％（7／9）、气短6627％（6／9），其他症状包括喘息11．1％（1／9）及声嘶22．2％（2／9）；胸部CT表现气道壁增厚、管腔狭窄达66．7％（6／9），2例患者出现气道钙化，2例患者伴有阻塞性肺炎；肺功能以阻塞性通气功能障碍为主，且在疾病早期即可出现；纤维支气管镜下所见主要为气道黏膜肿胀、软骨环消失、气道狭窄，病情较重者呼气相气道陷闭。【结论】RP患者呼吸道受累常见，需综合临床表现、胸部影像学、肺功能检查以及支气管镜镜下表现四个方面进行评估，方可确诊。[Objective] To summarize and evaluate the features of respiratory tract involvement ot relap- sing polychondritis（RP）. [MethodslThe features of RP patients with respiratory tract involvement were ana- lyzed retrospectively through clinical manifestation, chest radiological examination, pulmonary function test and the results of bronchoscopy. [Results] Respiratory tract involvement was commonly seen in RP patients. The common symptoms of respiratory tract involvement were cough （77. 8 %） and dyspnea （66. 7 G）. Other symptoms were wheezing（1.1%） and hoarseness（g2.2 %）. Chest CT showed airway wall thickening and lu- men stenosis（66.7 ~）. Two cases presented airway calcification. Two cases were companied with obstructive pneumonia. Pulmonary function test mainly showed obstructive ventilation defects, especially in early stages. Bronchoseopy revealed mucosa swelling of airway mucosa, dissolving of cartilage rings, airway stenosis. The collapse of airway in expiratory phase occurred in severe cases. [Conclusion] Respiratory tract involvement is commonly seen in RP patients. The comprehensive evaluation of clinical manifestation, chest iconography, lung ,function test and the results of hronchoscopy should be performed for the exact diagnosis.

关 键 词：多发性软骨炎 复发性 

分 类 号：R681.3[医药卫生—骨科学]