CXCL16/SR-PSOX与动脉粥样硬化的关系  

Correlation between CXCL16/SR-PSOX and Atherosclerosis

作　　者：赵君璧[1] 吴洁[1] 

机构地区：[1]南华大学附属第一医院心血管内科,湖南衡阳421001

出　　处：《医学综述》2012年第7期983-985,共3页Medical Recapitulate

摘　　要：动脉粥样硬化(AS)是一种多因素介导的血管慢性炎症疾病,趋化因子、清道夫受体和黏附因子是炎症过程中的重要因素。近年来新发现的分子蛋白——CXCL16/SR-PSOX逐渐引起了人们的重视。早期多项研究证实CXCL16/SR-PSOX兼具以上三种生物学效应,它一度被视为潜在的致AS因子,然而,此后一些试验结果却提示CXCL16/SR-PSOX可能具有抗AS的作用。血清CXCL16/SR-PSOX水平与AS间的关系同样存在争议。现就CXCL16/SR-PSOX的一般特征及其在AS中的作用和研究进展进行综述。Atherosclerosis（AS）is a multi-factor mediated chronic vascular inflammatory disease,and chemokines,scavenger receptors and adhesion molecules are important factors in this inflammatory process.In recent years,a newly discovered molecule protein—CXCL16/SR-PSOX has been attracting people′s attention gradually.Early studies confirmed that CXCL16/SR-PSOX had all the above mentioned three biological effects,and it was considered as a potential AS-promoting factor.However,some of the recent results of animal studies showed that CXCL16/SR-PSOX might have anti-atherosclerotic effects.In addition,the correlation between the level of serum CXCL16/SR-PSOX and coronary artery disease incidence and severity is also controversial.Here is to make a review on the general characteristics of CXCL16/SR-PSOX and the role it plays in AS.

关 键 词：趋化因子 清道夫受体 黏附因子 CXCL16/SR-PSOX 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]