免疫吸附治疗系统性红斑狼疮的临床分析  

Clinical Analysis of Immune Adsorption in the Treatment of Systemic Lupus Erythematosus

作　　者：杨祖成[1] 王丽[1] 马丽[2] 

机构地区：[1]泸州医学院附属医院风湿血液科,四川泸州646000 [2]泸州医学院,四川泸州646000

出　　处：《医学综述》2012年第7期1094-1095,共2页Medical Recapitulate

摘　　要：目的探讨免疫吸附对系统性红斑狼疮(SLE)的治疗效果。方法对12例重症SLE患者给予免疫吸附治疗,每次间隔3～5 d,连续2次,观察患者免疫吸附治疗前后抗核抗体、双链DNA抗体、免疫球蛋白LgG、补体C3指标变化程度及临床症状和体征的变化。结果抗核抗体、双链DNA抗体和免疫球蛋白LgG均有明显下降,补体C3升高,临床症状有不同程度的缓解。结论免疫吸附能有效控制SLE活动,明显改善临床症状,是治疗重症SLE的有效方法。Objective To investigate immunoadsorption therapeutic effect on systemic lupus erythematosus（SLE）.Methods 12 cases of severe SLE patients were given immunoadsorption therapy with an interval of 3-5 days,2 times continuously,patients were observed before and after immune adsorption treatment,antinuclear antibody,anti-double-stranded DNA,immunoglobulin LgG,complement C3 index variation and the clinical symptoms,signs of change.Results The antinuclear antibody,anti-double-stranded DNA and immunoglobulin LgG have decreased significantly,complement C3 increased,clinical symptoms have different degrees of mitigation.Conclusion Immune adsorption can effectively control SLE activities,improve clinical symptoms,and is an effective treatment of severe SLE.

关 键 词：免疫吸附 系统性红斑狼疮 自身抗体 免疫球蛋白 补体 

分 类 号：R593.24[医药卫生—内科学]