脑心清与抗痫药修复癫痫病人异常灌注灶的临床研究  

作　　者：王为民[1] 凡佩玉[1] 张玉琴[1] 杨玉霞[1] 宋文君[1] 党小利[1] 刘亚青[1] 

机构地区：[1]兰州大学第二医院癫痫中心 甘肃省癫痫防治中心,730030

出　　处：《当代医学》2012年第11期13-16,共4页Contemporary Medicine

摘　　要：目的探讨脑心清与抗痫药修复癫痫病人异常灌注灶的发作间期单光子发射断层扫描(SPECT)显像与长程视频脑电图(EEG)的变化。方法对100例癫痫病人治疗前后两次发作间期SPECT、长程EEG和CT/MRI检查。监测抗痫药及血浓度,控制平均24个月,加入中药脑心清治疗12个月。结果全身强直-阵挛发作(GTCS)62例,局灶性癫痫等38例。CT/MRI异常42例(42%)。SPECT异常81例(81%),异常灶153个,修复后正常增加18例(24.2%),总灶数减少61个(39.8%,P<0.05)。异常灶变化67%:长程EEG异常89例(89%),正常增加29例(29%,P<0.05)。痫样放电81例(90.0%),治疗减少40例(49.4%,P>0.05)。结论脑心清与抗痫药修复长期控制的癫痫异常灌注灶初步显示优越性。Objective To research result of repaired of abnormal perfusion foci of epilepsy with patients with antiepileptic drugs（AEDs）and NaoXinQing and changes of interictcal SPECT and long-term V-EEG. Methods The interictcal SPECT and long-term V-EEG and CT/MRI were performed in before and after treatment 100caes.The AEDs of blood concentration monitor of control treatmend 24 mcnth and NaoXinQing of chinese medicine in 12 mcnth .Results The GTCS in 62case and focal epilepsy etc in 38 cases.The CT/MRI abnormal were 42% .SPECT abnormal81 cases（81%）and abnormal perfusion foci 153 and after treatmend SPECT nomal to increase 18case（24.2.%）and abnormal perfusion foci to decrease 61 （39.8% P0.05）.and 67 case （67%）out of the abnormal perfusion foci showed changes after treatment. The long-term EEG abnormal 89case（ 89% ）and after treatment EEG normal to increase29.%（P0.05） and epileptic discharges before and after treatment 90.0% and 49.4%（P0.05）. Conclusion The results of AEDs and NaoXinQing with to repaired abnormal perfusion foci of epilepsy with patients in long-term control show have initial superiority.

关 键 词：癫痫 修复 脑心清 抗癫痫药 异常灌注灶 

分 类 号：R742.1[医药卫生—神经病学与精神病学]