高压氧治疗新生儿缺血缺氧脑病机制的研究  

Hyperbaric oxygen treatment of neonatal ischemia research on the mechanism of encephalopathy

作　　者：孔令霞[1] 常永霞[1] 许津莉[1] 麻利娟[1] 张凡[1] 席玉萍[1] 

机构地区：[1]河北北方学院附属第一医院,张家口075000

出　　处：《中国优生与遗传杂志》2012年第3期88-89,139,共3页Chinese Journal of Birth Health & Heredity

基　　金：张家口市2010年度科学技术研究与发展指导计划项目(课题编号:1021079D)

摘　　要：目的探讨高压氧干预新生儿缺血缺氧脑病(hypoxic-inchemic encephalopathy,HIE)的机制。方法选取40例患缺血缺氧脑病的新生儿,随机分成实验组和对照组各20例,对实验组进行高压氧、视、触、听觉和前庭功能早期干预,对照组只进行视、触、听觉和前庭功能训练,对两组新生儿进行生长激素(growth hormone,GH)和胰岛素样生长因子-Ⅰ(Insulin-like growth factor,IGF-Ⅰ)检测。结果 GH、IGF-1在实验组随着月龄的增长明显升高,在对照组也随着月龄的增长而升高,但增长幅度明显小于实验组。结论高压氧早期干预有利于缺血缺氧脑病患儿生长发育。Objective：To investigate the hyperbaric oxygen intervention neonatal hypoxic-ischemic encephalopathy（hypoxic-inchemic encephalopathy HIE） mechanism.Methods： 40 cases of newborns suffering from hypoxic-ischemic encephalopathy,were randomly divided into experimental group and control group 20 cases.Hyperbaric oxygen for experimental group,visual,tactile,auditory and vestibular function of early intervention in the control group only for visual,tactile,auditory and vestibular training.Two groups of newborns growth hormone（growth hormone GH） and insulin-like growth factor-Ⅰ（Insulin-like growth factor IGF-Ⅰ） detection.Results： Of GH,IGF-Ⅰ in the experimental group was significantly higher with the increase in age,in the control group also increased with the age of growth,but the growth rate significantly less than the experimental group.Conclusion： Hyperbaric oxygen to early intervention will help growth and development of hypoxic-ischemic encephalopathy.

关 键 词：高压氧 新生儿 缺血缺氧脑病 生长激素 胰岛素样生长因子 

分 类 号：R722.12[医药卫生—儿科]