萆苓方对糖尿病痛风模型大鼠血糖、血尿酸的影响及其抗炎作用的研究  

EXPERIMENTAL STUDY ON EFFECTS OF BILING PRESCRIPTION ON BLOOD SUGAR AND URIC ACID OF DIABETIC GOUT RATS AND ANTI - INFLAMMATORY EFFECT

作　　者：汪俊[1] 李中南[1] 李莉[1] 陈光亮[1] 

机构地区：[1]安徽中医学院第一附属医院,合肥230031

出　　处：《中国中医药科技》2012年第2期117-119,96,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：国家中医药临床研究基地糖尿病重点病种No.2008-12

摘　　要：目的:观察萆苓方对糖尿病痛风模型大鼠血糖、血尿酸和炎症因子的影响及其抗炎作用,探讨萆苓方对糖尿病痛风模型大鼠的保护作用机制。方法:采用链脲佐菌素腹腔注射复制糖尿病模型后,关节腔注射尿酸钠诱导痛风模型。Wistar大鼠随机分组,即正常组,模型对照组,萆苓方高、中、低剂量组,二甲双胍组,吲哚美辛组。分组给药后观察大鼠步态及关节肿胀度,并测定血糖、血尿酸、血清白介素-6、C-反应蛋白、肿瘤坏死因子-α的表达水平。结果:糖尿病痛风模型大鼠血糖、血尿酸、白介素-6、C-反应蛋白、肿瘤坏死因子的水平升高,步态异常,关节肿胀明显;萆苓方可明显干预上述变化。结论:萆苓方对糖尿病痛风有肯定疗效,其作机制与调节炎症因子有关。Objective: To explore the mechanism of biling prescription protecting diabetic gout by observing the effects of biling prescription on blood sugar,uric acid and serum inflammatory factors of diabetic gout rats and its anti - inflammatory function. Methods: Models with diabetes mellitus were made by interaperitoneal injecting streptozocin ( STZ ) and injecting uric acid solidumsalt at joint cavity to induce gout models. Rats were divided into normal,model,biling prescription low,middle and high dose and met- formin,indomethacin positive control groups. Observing rats’gait and girth of rats’right ankle at different periods,determining rats’ blood sugar,blood uric acid and serum IL - 6,CRP and TNF - α levels before treated and after treated 9 days. Results: Blood sugar,blood uric acid and serum IL - 6,CRP and TNF - α levels of model group were increased obviously,model rats’gait showed abnormally,model rats’ankles were obviously swell,biling prescription could significantly interfere the above chan- ges of diabetic gout rats,obviously reduce rats’blood sugar,blood uric acid and serum IL - 6,CRP,TNF - α levels,inhibit inflam- mation of diabetic gout rats. Conclusion: Biling prescription has definite anti - inflammatory and reduecing blood sugar,uric acid and serum IL - 6,CRP,TNF - α contents of diabetic gout rats.

关 键 词：糖尿病/中医药疗法 痛风/中医药疗法 @萆苓方/治疗应用 大鼠 

分 类 号：R285.5[医药卫生—中药学]