按摩退热作用的中枢机制及其穴位物质基础的研究  

The Study on Central Mechanism for Antipyretic Action of Massage and the Material Basis of Acupoints

作　　者：董新民[1] 朱漓[1] 张晓琼[1] 董泉声[1] 

机构地区：[1]四川省中医药科学院针灸经络研究所生理研究室,四川成都610031

出　　处：《四川中医》2012年第4期24-28,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省科技厅应用基础研究资助项目(B9524)

摘　　要：目的:阐明前期工作中所见按摩退热、散热效应的中枢机制及其与穴位感受系统的关系。方法:以肌松、清醒、行人工呼吸和内毒素化兔为对象,以视前区-下丘脑前部热敏神经元放电为指标,取轻、重按摩手法(直推与指压)分别刺激涌泉穴,对比观察内毒素化热敏神经元放电变化,反映按摩退热的中枢机制及其与穴位感受系统的关系。结果:内毒素抑制下丘脑热敏神经元活动(同时促进冷敏神经元放电),指压具有拮抗热原抑制热敏神经元活动的作用(P<0.01),因而可有促进散热和退热的功效,直推的此种效应则无统计学意义(P>0.05)。结论:按摩退热的中枢机制主要是按摩传入信号拮抗致热原对中枢温度敏感神经元活动的影响,从而促使正常机能的恢复;该类传入信号是由较重手法作用于穴位高阈细纤维感受系统(即按摩是项作用的穴位物质基础)而产生。Objective：To reveal central mechanism of antipyretic and thermolytic actions by massage in previous works and relationships of the central mechanism with the afferent system of acupoints.Methods：Stimulated＂Yongquan＂（K11）with heavy or light massage manipulation（straight push or finger-press manipulation）on rabbits which were on condition of muscle relaxation,consciousness,artificial respiration and endotoxinization.Meanwhile observed changes of discharge of heat sensitive neurons（HSNs）which were in the preoptic region and anterior hypothalamus（PO-AH）.The changes of discharge reflected the central mechanism of antipyretic and thermolytic actions by massage and relationships of the central mechanism with afferent system of certain acupoint which was material basis of acupoint.Results：Endotoxin inhibited activation of HSNs and promoted discharge of cold sensitive neureons（CSNs）,while finger-press manipulation could antagonize pyrogen as a result to affect activation of central temprature sensitive neurons（P0.01）.But using straight push manipulation to do the same thing had no statistically significant（P0.05）.Conclusion：The central mechanism of antipyretic action of massage is mainly to antagonize pyrogen as a result to affect activation of central temperature sensitive neurons and thus their normal function are recovered by afferent impules of high threshold fine fibre afferent system in acupoints during heavy massage,which is as same as previous work.With the result of this work properly discuss the research way which can find material basis of acupoints of effective action by massage.

关 键 词：按摩退热 中枢机制 POAH热敏神经元 穴位感受(传入)系统 

分 类 号：R244.1[医药卫生—针灸推拿学]