预混辅料直接压片的性质考察  

Property of direct compression on co-processed excipients

作　　者：任晓文[1] 王维[2] 丁一[3] 施拥骏 

机构地区：[1]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193 [2]天津中医药大学研究生部,天津300193 [3]天津药物研究院,天津300193 [4]国际药用辅料网,上海200090

出　　处：《现代药物与临床》2012年第2期107-110,共4页Drugs & Clinic

基　　金：国家重点基础研究发展计划项目(2010CB735602);国家重大新药创制专项(2011ZX09201-101-19;2011ZX09201-401-009);天津市科技支撑项目(09ZCKFSH01200)

摘　　要：目的考察几种预混辅料的性质。方法以粒度分布、休止角、堆密度为指标,考察预混辅料的粉体学性质,并将预混辅料应用于粉末直接压片工艺中。结果与普通辅料淀粉、微晶纤维素相比,预混辅料直压淀粉、直压微晶纤维素的休止角、压缩度小,流动性好。结论预混辅料的粉体学性质优于普通辅料,且粉末直接压片法所得片剂质量良好。Objective To investigate the properties of several co-processed excipients.Methods The characteristics of co-processed excipients were investigated by taking the size distribution,angle of repose,and bulk density as indexes,and excipients were applied to the direct compression.Results Compared with starch and microcrystalline cellulose,direct pressure starch and direct pressure microcrystalline cellulose had smaller repose angle and aerated bulk density,as well as excellent flow ability.Conclusion Compared with ordinary excipients,co-processed excipients show superior micromeritic characteristics,and we can obtain tablets of good quality by direct powder compression.

关 键 词：预混辅料 粉体学性质 粉末直接压片 

分 类 号：R944.2[医药卫生—药剂学]