天麻素对利多卡因致惊厥作用的影响  

The influence of Gastrodin on lidocaine-induced convulsion

作　　者：张素玲[1] 胡秋梅[1] 周新巧[1] 孙白云[1] 樊虹[1] 董娟娟[1] 李丽娜[1] 王丹[2] 

机构地区：[1]徐州医学院麻醉学院2008级2班,江苏徐州221004 [2]徐州医学院麻醉药理学教研室,江苏徐州221004

出　　处：《徐州医学院学报》2012年第2期81-83,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省高校自然科学基础研究项目（07KJD310219）

摘　　要：目的 观察天麻素单用及其与地西泮合用对利多卡因所致惊厥作用的影响.方法 腹腔注射不同剂量天麻素或天麻素和地西泮合用,10 min后,腹腔注射致惊厥剂量的利多卡因,观察小鼠惊厥潜伏期、持续时间和惊厥只数.结果 天麻素100 mg·kg-1、200 mg·kg-1、400 mg·kg-1能延长惊厥潜伏期（P〈0.05,P〈0.05,P〈0.01）;单独使用天麻素50 mg·kg-1可延长惊厥潜伏期（P〈0.05）,对惊厥持续时间和惊厥只数则无明显影响,单独使用地西泮1.5 mg·kg-1对惊厥潜伏期、持续时间和惊厥只数均无明显影响,二者合用则能明显延长惊厥潜伏期（P〈0.01）,缩短惊厥持续时间（P〈0.01）,减少惊厥只数（P〈0.01）.结论 单用天麻素可拮抗利多卡因的致惊厥作用,小剂量天麻素与地西泮合用能协同拮抗利多卡因所致惊厥作用.Objective To observe the influences of Gastrodin alone and combined with diazepam on lidocaine - induced convulsion. Methods Convulsant dose of lidocaine was administered intraperitoneally 10 minutes after Gastrodin or Gastrodin and diazepam had been administered intraperitoneally. The convulsion latency, convulsion duration and con- vulsion number were observed. Results Gastrodin （100 mg·kg-1 , 200 mg·kg-1 , 400 mg·kg-1 ） could extend the convulsion latency （P 〈0. 05, P 〈0. 05, P 〈0.01 ）; Gastrodin （50 mg·kg-1） alone could extend the convulsion la- tency （ P 〈 0.05 ） , but had no significant differences on the convulsion duration and convulsion number, diazepam （ 1.5mg·kg-1 ） alone had no significant differences on the convulsion latency, eonvulsdon duration and convulsion number. However, Gastrodin combined with diazepam could extend the convulsion latency （P 〈 0.01 ） , shorten the convulsion du- ration （P〈0.01） , and reduce the convulsion number （P〈0.01） significantly. Conclusion Gastrodin alone can an- tagonize lidocaine - induced convulsion, and small does of Gastrodin combined with diazepam reveal a synergistic influ- ence.

关 键 词：天麻素 利多卡因 地西泮 惊厥 小鼠 

分 类 号：R285.5[医药卫生—中药学] R971.2[医药卫生—中医学]