萘普生固体分散体的研制  

Preparation of naproxen solid dispersion

作　　者：杨宜华[1] 廉淑芹[1] 邵云云[1] 

机构地区：[1]徐州医学院药学院,江苏徐州221004

出　　处：《徐州医学院学报》2012年第2期88-91,共4页Acta Academiae Medicinae Xuzhou

摘　　要：目的 制备萘普生-聚乙二醇6000（PEG6000）固体分散体,分析萘普生药物溶出速率和溶解度.方法 萘普生与PEG6000按照不同的的质量比例,采用熔融法制备固体分散体;通过紫外光谱、红外光谱、体外溶出及溶解度检测对固体分散体进行分析.结果 紫外光谱和红外光谱均验证固体分散体的形成.与萘普生原料药相比,萘普生固体分散体的溶出速率和溶解度均提高.结论 萘普生-PEG6000固体分散体能显著提高萘普生溶出速率和溶解度,且随着载体比例的增大,溶出速率和溶解度也增大.Objective To prepare solid dispersions of naproxen with polyethylene glycol 6000 （PEG6000） to improve its dissolution and solubility. Methods The solid dispersions of naproxen were prepared by the fusion method with PEG6000 as the carrier. Evaluation of the properties of the dispersions was performed by ultraviolet spectroscopy, infrared spectroscopy, dissolution and solubility studies. Results There was no new substance produced by naproxen and PEG6000. Compared with crude drug, the dissolution rate and the solubility of solid dispersions were increased immensely. Conclusion The dissolution and solubility of naproxen can be improved significantly in solid dispersion with PEG6000. With the increase of the proportion of the carrier, the dissolution rate and solubility of solid dispersions be- come greater.

关 键 词：萘普生 聚乙二醇6000 固体分散体 溶出速率 溶解度 

分 类 号：R944.9[医药卫生—药剂学]