青霉素制备青霉素亚砜的研究  

Preparation of Penicillin G S-Oxide from Penicillin G

作　　者：史兰香[1] 陈焕章[1] 赵地顺[1] 徐志栋[1] 荣杰[1] 

机构地区：[1]河北科技大学化学与制药工程系,河北石家庄050018

出　　处：《精细化工》2000年第5期252-255,276,共5页Fine Chemicals

基　　金：河北省科委资助项目! ( 972 1 3 0 52D)

摘　　要：以青霉素G钾盐与低质量分数过氧乙酸为原料氧化制备青霉素亚砜 ,其最佳工艺条件为 :n(C16 H18N2 O4 SK)∶n(CH3CO3H) =1 .0∶( 1 1～ 1 2 ) ,反应温度 0～ 5℃ ,反应时间 2 .0～ 2 5h ,w(CH3CO3H) =8 5% ,w(CH3CO2 H) =1 0 %。青霉素亚砜收率达 96 8%。同时建立了青霉素亚砜的半定量分析方法 ,以硅胶G为固定相 ,以V(CH3CO2 C4 H9 n)∶V(CH3CO2 H)∶V(NaH2 PO4 -H2 O)∶V(C4 H9OH n) =6.0∶2 .0∶1 .0∶0 5为流动相 ,用TLC法对产品进行半定量分析检测 ,并经IR、MS谱图验证了产品结构。Penicillin G S oxide was synthesized with penicillin G and acetic hydroperoxide of low concentration.The optimal reaction conditions were as follows:mole ratio of penicillin G∶acetic hydroperoxide=1.0∶(1.1-1.2),reaction temperature 0-5 ℃,reaction time 2.0-2.5 h,concentration of acetic hydroperoxide 8 5%,concentration of acetic acid 10%.The yield of product was 96 8%.Moreover,the method of thin layer chromatography for identification of penicillin G S oxide was established with mobile phase of n butyl acetate-acetic acid-sodium dihydrogen phosphate n butanol(6.0∶2.0∶1.0∶0 5 by volume).The structure of the product was identified with IR and MS.

关 键 词：青霉素 青霉素亚砜 青霉素G 抗菌素 

分 类 号：TQ465.1[化学工程—制药化工]