头孢哌酮钠他唑巴坦钠皮肤试验致严重过敏反应  

Severe anaphylactic reactions induced by skin allergy test of cefoperazone sodium and tazobactam sodium

作　　者：龙明立[1] 

机构地区：[1]长沙市中心医院药学部临床药学研究室,410004

出　　处：《药物不良反应杂志》2012年第1期57-59,共3页Adverse Drug Reactions Journal

摘　　要：1例50岁男性肺癌患者因肺部感染应用左氧氟沙星,由于疗效不佳欲换用头孢哌酮钠他唑巴坦钠。行皮肤过敏试验约10 min后,患者出现胸闷、心悸、气促、呼吸困难,心率120次/min。考虑为过敏反应,立即给予地塞米松10 mg静脉推注,行心电监护。1.5 h后,患者胸闷、气促及呼吸困难等症状改善,血气分析示二氧化碳分压26 mm Hg(1 mm Hg=0.133 kPa),氧分压47 mm Hg,实际碳酸氢盐19 mmol/L,标准碳酸氢盐22 mmol/L,pH 7.49。8 h后,患者过敏反应症状消失。A 50-year-old male with pulmonary infections received levofloxacin, as a result of poor effect, was ready to switch to cefoperazone sodium and tazobactam sodium. About 10 minutes after a skin allergy test was carried out, the patient experienced chest distress, palpitations, shortness of breath, dyspnea, heart rate was 120 beats/min. Cefoperazone sodium and tazobactam sodium- induced anaphylaetic reactions was considered, dexarnethasone 10 mg was given by IV bolus immediately and underwent electrocardiogram monitoring. His symptoms such as chest distress, shortness of breath, and dyspnea were improved 1.5 hours later. Blood gas analysis indicated：PCO2 26 mrn Hg, PO2 47 mm Hg, HCO3 - act 19 rnmol/L, HCO3 - std 22 mmol/L, pH 7.49. After 8 hours, the symptoms of allergic reactions subsided.

关 键 词：头孢哌酮 皮肤试验 过敏反应 

分 类 号：R595.3[医药卫生—内科学]