依达拉奉辅助高压氧治疗重度CO中毒临床疗效分析  

Clinical curative effects of hyperbaric oxygen assisted by edaravone on severe carbon monoxide poisoning

作　　者：王晓梅[1] 施阳[1] 董芸[1] 张建成[1] 

机构地区：[1]四川省人民医院急救中心,成都610072

出　　处：《西南国防医药》2012年第4期391-394,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的总结分析依达拉奉辅助高压氧治疗重度CO中毒的近期及远期临床疗效。方法以我院2005年1月～2011年1月收治的重度CO中毒119例患者为研究对象,根据治疗方案分为对照组和依达拉奉组,对照组为常规急救及高压氧治疗,依达拉奉组在对照组治疗基础上,加用依达拉奉注射液治疗,观察两组患者的近期和远期疗效。结果依达拉奉组昏迷持续时间为(15.8±2.4)h,显著少于对照组的(17.4±3.3)h;治疗后血清LDH水平显著低于对照组,PaO2和SaO2显著高于对照组。对照组和依达拉奉组总有效率分别为85.3%和93.2%,两组临床有效率比较无显著性差异(χ2=1.646,P>0.05)。依达拉奉组痊愈率(59.1%)显著高于对照组的40.0%(χ2=4.057,P<0.05),迟发型脑病发生率(7.3%)显著低于对照组的21.9%(χ2=3.903,P<0.05),晚期并发症发生率(9.8%)低于对照组的26.6%(χ2=4.412,P<0.05)。结论依达拉奉辅助治疗可显著减少昏迷时间,提高痊愈率,降低并发症的发生。Objective To summarize and analyze the short and long term clinical curative effects of hyperbaric oxygen assisted by edaravone on patients with severe carbon monoxide poisoning.Methods 119 patients with severe carbon monoxide poisoning hospitalized from January,2005 to January,2011 were selected as the subjects.They were divided into control group and edaravone group according to treatments they received.Patients in the control group were treated by conventional first-aid and hyperbaric oxygen.And those in the edaravone group were treated by edaravone injection based on the above treatment.The short and long term curative effects in both groups were summarized.Results The coma duration time of the edaravone group（15.8± 2.4）h was significantly less than that of the control group（17.4 ± 3.3）h.After the treatment,the serum LDH level of the edaravone group was significantly lower and PaO2 and SaO2 were significantly higher than thsoe of the control group.The total effective rates of the control group and the edaravone group were 85.3% and 93.2%,respectively.And there was no significant difference in the clinical effective rate between the two groups（χ^2=1.646,P〈0.05）.The recovery rate of the edaravone group（59.1%）was significantly higher than that of the control group（40.0%,χ^2=4.057,P〈0.05）.The incidence of forme tardive encephalopathy（7.3%）was significantly lower than that of the control group（21.9%,χ^2=3.903,P〈0.05）.The incidence of late complications（9.8%）was lower than that of the control group（26.6%,χ^2=4.412,P〈0.05）.Conclusion The adjuvant therapy with edaravone can significantly reduce the duration time of coma,increase the recovery rate and reduce the incidence of complications.

关 键 词：一氧化碳 中毒 高压氧 依达拉奉 

分 类 号：R595.1[医药卫生—内科学]