低强度脉冲超声对美蓝渗入正常兔膝关节软骨的作用  

Low intensity pulsed ultrasound for promoting penetration of methylene blue into knee cartilage of normal rabbit

作　　者：周崑[1] 周伟[2] 陈文直[1] 王智彪[1] 

机构地区：[1]重庆医科大学附属第二医院HIFU肿瘤中心,重庆400010 [2]四川省广安市人民医院内三科,广安638001

出　　处：《重庆医科大学学报》2012年第2期121-124,共4页Journal of Chongqing Medical University

摘　　要：目的:观察低强度脉冲超声(Low intensity pulsed ultrasound,LIPU)对美蓝渗入正常兔膝关节软骨的作用。方法:向9只成年健康新西兰兔膝关节腔内注射0.1%美蓝溶液0.5 ml,随机选择一侧作为治疗组给予5 min LIPU治疗,另一侧作为对照组进行假治疗。随后处死实验兔,取股骨髁间窝关节软骨标本,在解剖显微镜下拍照。测量照片上美蓝从软骨表面渗入软骨内的深度,将测量结果作配对分析。结果:5 min LIPU治疗组美蓝渗入兔膝关节软骨较假治疗组深,差异有统计学意义(P<0.05)。结论:LIPU能促进美蓝渗入正常兔膝关节软骨,可能会增加关节软骨营养。Objective：To observe the effect of low intensity pulsed ultrasound（LIPU） on penetration of methylene blue into knee cartilage of normal rabbit.Methods：5 ml 0.1% Methylene blue solution were injected into both articular cavities of hind legs of nine New Zeland rabbits.One of the hind legs of each rabbit was distributed randomly into treatment group and treated with LIPU,while the other into control group with dummy treatment.All animals were sacrificed after a five-minute LIPU treatment.Cartilages of femur intercondylar fossa were removed and cut into slices,and the photos were taken under anatomic microscope.The depths of methylene blue penetrating into articular cartilage were measured.Pair matched analysis was performed to learn if there is a signifficent difference between the two groups.Results：Penetration of methylene blue into articular cartilage in LIPU group were deeper than that in control group（P0.05）.Conclusion：LIPU enhances methylene blue penetration into articular cartilage,which indicates LIPU may improve nutrition supply of articular cartilage.

关 键 词：超声治疗 软骨 关节 

分 类 号：R454.3[医药卫生—治疗学]