影响健康人血浆D-二聚体的因素  

Factors influencing plasma D-dimer levels in healthy people

作　　者：李丹丹[1,2] 马聪[2] 马学斌[2] 杨明[2] 

机构地区：[1]广州南方医科大学研究生院,广州510515 [2]海军总医院检验科,北京100048

出　　处：《军医进修学院学报》2012年第4期369-371,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的研究影响健康人群血浆D-二聚体增高的因素。方法选择健康体检者164例,按年龄将D-二聚体分为:≤49岁、50-59岁、60-69岁和≥70岁四组;按D-二聚体参考值上限232ng/ml,将D-二聚体分为三组:低值组(<100ng/ml)、中值组(100-232ng/ml)和高值组(>232ng/ml)。实验室方法用乳胶增强免疫比浊法检测血浆D-二聚体含量。结果各年龄组D-二聚体水平有统计学差异(P<0.01),LogD-二聚体与年龄呈正相关(r=0.38,P<0.05),回归方程为LogD-二聚体=1.38+0.01×年龄。二分类Logistic回归分析结果,年龄、纤维蛋白原、平均红细胞体积是D-二聚体的独立相关因素。结论影响健康人血浆D-二聚体水平的因素是年龄、纤维蛋白原水平和平均红细胞体积。Objective To study the factors influencing plasma D-dimer levels in healthy people.Methods One hundred and sixty-four healthy people were divided into≤49 years old group,50-59 years old group,60-69 years old group,and ≥70 years old group,according to their D-dimer levels.D-dimer levels were divided into 100ng/ml group,100-232ng/ml group,and 232ng/ml group according to its upper limit value（232ng/ml）,and measured by turbidimetric quantitative immunoassay.Results The D-dimer levels were significantly different in different age groups（P0.01）.The LogD-dimer level was positively correlated with age（r=0.38,P0.05） and the regression equation was ＂logD-dimer=1.38＋0.01×age＂.Binary logistic regression analysis showed that age,fibrinogen level and mean red cell volume were the independent risk factors for D-dimer.Conclusion Age,fibrinogen level and mean red cell volume are the factors that influence the plasma D-dimer levels in healthy people.

关 键 词：D-二聚体 纤维蛋白原 红细胞体积 

分 类 号：R446.11[医药卫生—诊断学]