对ABO血型不合的干细胞移植患者输血方案分析  

Analysis of transfusion protocol for patients undergoing ABO incompatible allogeneic stem cell transplantation

作　　者：闫石[1] 韩明哲[1] 韩敬淑[1] 焦淑贤[1] 杨丛林[1] 孙福军[1] 冯泗洲 王薇[1] 姚锡美 陆荣[1] 张新德 张薇[1] 赵英新[1] 

机构地区：[1]中国医学科学院

出　　处：《临床血液学杂志》2000年第3期99-101,共3页Journal of Clinical Hematology

摘　　要：目的 :对 ABO血型不合的异基因造血干细胞移植患者输血状况及血液成分选择进行探讨。方法 :对异基因造血干细胞移植供受者进行 ABO血型鉴定 ,并对 2 8例 ABO血型不合患者的临床输血种类、输血量、红细胞血型转变时间及造血干细胞植活时间进行统计与比较。结果 :15例 ABO主侧不合的干细胞移植者 ,血型转变时间明显延长 ( P <0 .0 1) ,输注红细胞的量明显高于 ABO相合者 ( P <0 .0 5 )。 13例 ABO次侧不合者输注红细胞量虽然高于相合者 ,但无统计学意义 ( P>0 .0 5 )。输注血小板的量和白细胞恢复时间 ,ABO相合与不合者无明显差异。结论 :ABO不合的干细胞移植患者输血 。Objective: To explore the blood component selection and transfusion for patients undergoing major ABO incompatible allogenic stem cell transplantation.Methods: ABO blood group was identified in recipients and donors of allogenic stem cell transplantation, and the blood component and amount, the time for RBC blood group transversion and stem cell engraftment were analyzed in 28 patients undergoing ABO incompatible transplantation. Results: Compared with patients undergoing ABO compatible transplantation, the time for blood group transversion was significantly prolonged (P< 0.01 )and more RBC transfusions were required in 15 patients undergoing major ABO incompatible transplantation (P< 0.05 ). And the amount of RBC transfusions was also higher in 13 patients undergoing minor ABO incompatible transplantation (P> 0.05 ). The time for stem cell engraftment and the platelet concentrates transfusions were not significantly different between patients undergoing ABO compatible and incompatible transplantation.Conclusion:RBCs and platelet with me not destroyed by the recipients′ serum agglutinin were required for patients undergoing ABO incompatible allogenic stem cell transplantation.

关 键 词：ABO血型系统 血型不合 干细胞移植 输血 

分 类 号：R457.1[医药卫生—治疗学]