Optimized Palladium（0）-catalyzed Suzuki Cross-coupling Reaction of Polystyrene-supported Selenenyl Flavanones： A Convenient Preparation of Biaryl-chromen-4-one  

作　　者：汤峨 李文 高占勇 张莲蓬 马秋石 

机构地区：[1]Key Laboratory of Medicinal Chemistry of Natural Resource(Yunnan University),Ministry of Education,Kunming,Yunnan 650091,China [2]Department of Applied Chemistry,Yunnan University,Kunming,Yunnan 650091,China

出　　处：《Chinese Journal of Chemistry》2012年第3期585-589,共5页中国化学（英文版）

摘　　要：Application of the Suzuki cross-coupling reaction for efficient synthesis of diverse substituted biaryl-chromen- 4-ones using an optimized palladium（0） catalyst system is reported. The coupling of arylboronic acids with the resin-bound bromoflavanones which were prepared by organoselenium-induced regioselective intramolecular cy- clization of bromo-2-hydroxylchalcones proceeded smoothly. Biaryl-chromen-4-ones were synthesized by subse- quent selenoxide syn-elimination in good total yields.Application of the Suzuki cross-coupling reaction for efficient synthesis of diverse substituted biaryl-chromen- 4-ones using an optimized palladium（0） catalyst system is reported. The coupling of arylboronic acids with the resin-bound bromoflavanones which were prepared by organoselenium-induced regioselective intramolecular cy- clization of bromo-2-hydroxylchalcones proceeded smoothly. Biaryl-chromen-4-ones were synthesized by subse- quent selenoxide syn-elimination in good total yields.

关 键 词：biaryl-chromen-4-ones Suzuki coupling solid-phase synthesis palladium（O） selenium 

分 类 号：TQ325.1[化学工程—合成树脂塑料工业] O753.2[理学—晶体学]