Efficient Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives via One-pot Two- step Metal-catalyzed Three-component Reactions  

作　　者：吴磊 孙晶 颜朝国 

机构地区：[1]College of Chemistry&Chemical Engineering Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Journal of Chemistry》2012年第3期590-596,共7页中国化学（英文版）

摘　　要：A sequential one-pot two-step reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]- quinoline derivatives in good yields has been successfully developed. The reaction included firstly Cu-catalyzed three-component reaction of isoquinoline （quinoline）, acetylenedicarboxylate and alkynylbenzene and then Pd-catalyzed intramolecular C（sp）-C（sp^2） coupling reaction of initially formed 1-alkenyl-2-alkynyl- 1,2-dihydroiso- quinoline （1,2-dihydroquinoline）.A sequential one-pot two-step reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]- quinoline derivatives in good yields has been successfully developed. The reaction included firstly Cu-catalyzed three-component reaction of isoquinoline （quinoline）, acetylenedicarboxylate and alkynylbenzene and then Pd-catalyzed intramolecular C（sp）-C（sp^2） coupling reaction of initially formed 1-alkenyl-2-alkynyl- 1,2-dihydroiso- quinoline （1,2-dihydroquinoline）.

关 键 词：INDOLIZINE pyrrolo[2 1-a]isoquinoline ISOQUINOLINE C-C coupling reaction three-component reaction 

分 类 号：TQ225[化学工程—有机化工] O626.323[理学—有机化学]