MCH、α-HBDH联合检测在巨幼红细胞性贫血中的诊断价值  

Diagnostic value of combined detection of MCH and α-HBDH for megaloblastic anemia

作　　者：栾正云[1] 张立新[1] 叶军[1] 陈静波[1] 陆桃红[1] 李林[1] 

机构地区：[1]泰州市人民医院临床医学研究所,江苏泰州225300

出　　处：《海南医学》2012年第8期92-94,共3页Hainan Medical Journal

摘　　要：目的评估MCV、MCH、RDW和α-HBDH对于巨幼红细胞性贫血在大细胞性贫血中的鉴别诊断能力。方法检测巨幼红细胞性贫血(MA)34例、溶血性贫血(HA)16例和骨髓增生异常综合征(MDS)25例的MCV、MCH、RDW-CV和α-HBDH水平,采用ROC曲线评估这些指标各自的诊断效率,选择最佳的诊断指标。结果 Logistic回归结果显示MCH、HBDH为MA独立预测因子,MCH、α-HBDH、MCH联合α-HBDH的三条曲线线下面积分别为0.746,0.719,0.801。结论 MCH、α-HBDH联合检测对于从常见大细胞性贫血中帮助鉴别诊断出MA是更加有效的方法。Objective To evaluate the value of MCV,MCH,RDW,α-HBDH in the diagnosis of megaloblastic anemia（MA）,discriminating from macrocytic anemia.Methods The levels of MCV,MCH,RDW-CV,α-HBDH of patients with MA（34 cases）,hemolytic anemia（HA,16 cases）,myelodysplastic syndrome（MDS,25 cases） were detected.Their diagnostic efficiency was evaluated through ROC curve in order to find the optimal diagnostic index.Results Logistic regression displayed that MCH,HBDH were independent predictors for MA diagnosis.The areas under the curves of MCH,α-HBDH,MCH combined with α-HBDH were 0.746,0.719 and 0.801,respectively.Conclusion Detection of MCH combined with α-HBDH was more effective for MA diagnosis from common macrocytic anemia.

关 键 词：巨幼红细胞性贫血 溶血性贫血 骨髓增生异常综合征 大细胞性贫血 红细胞平均容积 红细胞平均血红蛋白量 红细胞分布宽度 Α-羟丁酸脱氢酶 

分 类 号：R556.6[医药卫生—血液循环系统疾病]