左旋精氨酸对体外循环缺血再灌注损伤心肌的保护作用  

Protective Effect of L-arginine on Postischemia Reperfusion Myocardium During Extracorporeal Circulation

作　　者：林丽娜[1] 王万铁[2] 徐正祄 李东 

机构地区：[1]温州医学院附属第一医院麻醉科,温州325003 [2]温州医学院附属第一医院病理生理教研室 [3]温州医学院附属第一医院检验系分析中心

出　　处：《中国胸心血管外科临床杂志》2000年第2期89-91,共3页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：浙江省教委科研基金! ( 97161)

摘　　要：Objective\ To explore the protective effects of L arginine on myocardial ischemia reperfusion injury in patients undergoing extracorporeal circulation(ECC).\ Methods\ Sixteen patients undergoing open heart surgery were randomly divided into two groups:control group( n=8) and treated group( n=8) . Before aortic clamping and 2 hours, 4 hours, 8 hours after aortic off clamping, blood samples were taken to measure the levels of nitric oxide(NO), the activities of lactic dehydrogenase (LDH) and crentine phosphokinase (CPK).\ Results\ In control group NO level decreased remarkably ( P <0.05 or P<0.01) and LDH or CPK activity increased significantly ( P<0.01) at different time points after aortic off clamping as compared with that before aortic clamping; In treated group NO level did not decrease and activities of LDH and CPK increased slightly, and there were significant differences about parameters as above between control group and treated group ( P<0.05 and P<0 01) .\ Conclusion\ L arginine has notable protective effects on postischemia reperfusion myocardium during extracorporeal circulation which is due to its raising NO level.Objective\ To explore the protective effects of L arginine on myocardial ischemia reperfusion injury in patients undergoing extracorporeal circulation(ECC).\ Methods\ Sixteen patients undergoing open heart surgery were randomly divided into two groups:control group( n=8) and treated group( n=8) . Before aortic clamping and 2 hours, 4 hours, 8 hours after aortic off clamping, blood samples were taken to measure the levels of nitric oxide(NO), the activities of lactic dehydrogenase (LDH) and crentine phosphokinase (CPK).\ Results\ In control group NO level decreased remarkably ( P <0.05 or P<0.01) and LDH or CPK activity increased significantly ( P<0.01) at different time points after aortic off clamping as compared with that before aortic clamping; In treated group NO level did not decrease and activities of LDH and CPK increased slightly, and there were significant differences about parameters as above between control group and treated group ( P<0.05 and P<0 01) .\ Conclusion\ L arginine has notable protective effects on postischemia reperfusion myocardium during extracorporeal circulation which is due to its raising NO level.

关 键 词：左旋精氨酸 体外循环 心肌再灌注损伤 一氧化氮 

分 类 号：R605[医药卫生—外科学]