非洛地平的新型合成工艺研究  

Synthesis of Felodipine

作　　者：钱青[1] 张钦宇[1] 邓莉平[1] 

机构地区：[1]绍兴文理学院化学化工学院,浙江绍兴312000

出　　处：《绍兴文理学院学报》2012年第7期5-8,60,共5页Journal of Shaoxing University

摘　　要：以2,3-二氯苯甲醛、乙酰乙酸甲酯和3-氨基巴豆酸乙酯为起始原料,经过Knoevena gel缩合及Michael反应环合得到非洛地平.研究表明,该路线简单可靠,安全性高,对环境污染小,药物的毒性残留低,后处理工艺高效.Felodipine was synthesized from 2,3-dichlorobenzene formaldehyde,methyl acetoacetate and 3-amino-ethyl crotonate via a sequence of Knoevena gel condensation and Michael cyclization.Research shows that the method was simple and easy to control,the reaction process was friendly to the environmental,drug toxicity remained low,and post-treatment processes were effective.

关 键 词：非洛地平 乙酰乙酸乙脂 KNOEVENAGEL缩合 Michael反应环合 

分 类 号：TQ463[化学工程—制药化工]