无肝素及低分子肝素在有出血倾向的血液透析患者的应用研究  

Comparison of Anticoagulation Using Beparin-free and Low Molecular Weight Heparins in Hemodialysis Patients with Risk of Bleeding

作　　者：王春来[1] 李晶晶[1] 

机构地区：[1]辽宁省锦州市中心医院,121000

出　　处：《实用心脑肺血管病杂志》2012年第4期681-682,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的研究无肝素及低分子肝素在有出血倾向的血液透析患者的应用安全性和有效性。方法选择伴有中、高危出血倾向的维持性血液透析(MHD)患者24例,随机分为A组12例(无肝素透析),B组12例(低分子肝素透析),观察临床出血情况,透析前后部分凝血酶活化时间、凝血酶原时间、血小板、管道及透析器凝血情况。结果透析后两组无一例出血加重,A组7例发生凝血,B组无体外凝血发生。结论无肝素与低分子两种透析抗凝方法,低分子肝素透析明显优于无肝素。Objective To investigate the efficacy and safety of heparin - free and low molecular weight heparin antieo- agulation in hemodialysis patients with high risk of bleeding. Methods Twenty - four patients were random ized in this study and divided into two groups, twelve patients in heparin - free group and twelve patients in LMWH group. The incidence of bleeding and the dialyser coagulation as well as Activated Partial Throm boplastin Time and the platelet count were obseved at the baseline and after hemodialysis. Results Bleeding was not increased in both group. Conclusion In hemodialysis, patients suffering from high risk of bleeding the two methods of antieoagulation show the satisfactory efficiency. In comptarison with hepria - free LMWH is Asafe and feasible alternative.

关 键 词：血液透析 抗凝 低分子肝素 

分 类 号：R554[医药卫生—血液循环系统疾病]