壳聚糖基纤维止血效果研究  

Study of Hemostatic Effect of Chitosanbased Fibre

作　　者：高金伟[1] 刘万顺[2] 韩宝琴[2] 

机构地区：[1]天津农学院水产科学系天津市水产生态及养殖重点实验室,天津300384 [2]中国海洋大学海洋生命学院225实验室,山东青岛266003

出　　处：《安徽农业科学》2012年第11期6458-6459,共2页Journal of Anhui Agricultural Sciences

摘　　要：[目的]探讨壳聚糖基纤维对肝脏的止血效果。[方法]建立兔肝脏出血模型。试验组使用壳聚糖基纤维贴敷创面,对照组使用速即纱,空白组不使用任何材料。术后观察止血效果,记录各组的总出血量和止血率。[结果]试验组在观察期无出血现象,止血率为100%,出血量为(0.443±0.030)g/kg,显著优于对照组和空白组(P<0.05)。[结论]壳聚糖基纤维对肝脏创面止血效果显著,为进一步开展临床试验提供了依据。[Objective] The aim was to discuss the hemostatic effects of chitosanbased fibre for liver.[Method] The hemorrhage model of rabbit liver was established.Hemostasis was performed with chitosan-based fibre in experimental group,surgicel in control group and without any material in blank group.The hemostatic effects were evaluated by total blood loss（TBL） and hemostatic rate.[Result]Experimental group had no bleeding in observation period,the hemostatic rate was 100% and the blood loss was only（0.443±0.030）g/kg,better than the control group and blank group（P0.05）.[Conclusion]Chitosanbased fibre has effective hemostasis in liver wound,which will provide reliable information for the clinical trials.

关 键 词：壳聚糖基纤维 止血 出血量 止血率 

分 类 号：S13[农业科学—农业基础科学] R282[医药卫生—中药学]