青蒿联合甲氨蝶呤对类风湿性关节炎患者血TNF-α、IL-10水平的影响  

Influence of Artemisia Annua Combined with Methotrexate on Levels of TNF-alpha,IL-10 of Patients with Rheumatoid Arthritis

作　　者：李燕[1] 胡俊平[1] 巫婷婷[1] 

机构地区：[1]中国人民解放军第452医院,四川成都610021

出　　处：《河南中医》2012年第4期433-435,共3页Henan Traditional Chinese Medicine

基　　金：四川省卫生厅课题(编号:080094)

摘　　要：目的:探讨中药青蒿联合甲氨蝶呤对类风湿性关节炎(rheumatoid arthritis,RA)患者血IL-10、TNF-α水平的影响。方法:将50例活动性类风湿性关节炎患者随机分为2组,对照组口服甲氨蝶呤10 mg,每周1次;治疗组在对照组治疗的基础上加用中药青蒿20 g治疗,日1剂,水煎服,12周为1个疗程,1个疗程后用ELISA法检测2组患者治疗前后血清TNF-α、IL-10水平。结果:治疗后两组患者血清IL-10水平均较治疗前显著升高(P﹤0.05),但2组比较无明显差异(P>0.05)。治疗后治疗组TNF-α水平较治疗前降低(P﹤0.05);2组治疗后TNF-α水平比较,差异有显著性(P﹤0.05)。结论:中药青蒿联合小剂量甲氨蝶呤治疗RA优于单独使用甲氨蝶呤。Objective： To investigate the influence of artemisia annua and methotrexate on the levels of TNF -alpha, IL- I0 of patients with rheumatoid arthritis. Methods： 50 patients with active rheumatoid arthritis were randomly divided into two groups. The control group was treated with methotrexate. 10 mg weekly. The treatment group, on the basis of the treatment of control group, was treated with artemisia annua, 20 g a day, administration in decoction, 12 weeks of a course of treatment. The serum levels of TNF - alpha. IL - 10 of the two groups were detected with ELISA ＇after a course of treatment. Results： After the treat- ment, the serum IL- 10 levels of two groups significantly increased （P 〈0.05） compared with those before the treatment, bu! there was no significanl difference between 2 groups （ P 〉 0. 05 ）. TNF - tx level of the treatment group decreased （ P 〈 0.05 ） compared with that before the treatment ： there was significant difference （ P 〈0. 05 ） in TNF - a levels of two groups after the eatment. Conclusion ： Artemisia annua combined with low dose methotrexate in treating RA is superior to the single use of methotrexate.

关 键 词：类风湿性关节炎 甲氨蝶呤 青蒿 TNF-Α IL-10 

分 类 号：R593.22[医药卫生—内科学]