妊娠期高血压疾病产妇脐血清TNF-α含量影响  

Effect on Maternal Umbilical Vein Serum Levels of TNF-α of Pregnancy induced Hypertension

作　　者：刘春 

机构地区：[1]武侯区人民医院妇产科,四川成都610000

出　　处：《中国医药指南》2012年第9期38-39,共2页Guide of China Medicine

摘　　要：目的探讨妊娠期高血压疾病产妇脐静脉血清肿瘤坏死因子-α(TNF-α)表达含量和意义。方法选择妊娠期高血压疾病产妇30例作为观察组(按照病情轻重分成子痫前期轻度组、子痫前期中度组、子痫组共三个亚组),30例正常产妇作为对照组。产妇胎盘娩出后抽取胎盘端脐静脉血并分离血清,通过ELISA法分别检测血清TNF-α的含量。结果妊娠期高血压疾病产妇脐静脉血清TNF-α含量([60.69±0.45)ng/L]明显较正常组高[(14.05±0.53)ng/L],差异有统计学意义(P<0.05)。妊娠期高血压疾病产妇各亚组之间TNF-α含量随病情加重而增加,各亚组间差异有统计学意义。结论妊娠高血压疾病可引起产妇脐静脉血TNF-α等有害因子增加。Objective To investigate expression content and meaning of tumor necrosis factor-α（TNF-α） in maternal umbilical vein serum of Pregnancy induced hypertension.Methods 30 cases of Pregnancy induced hypertension as the observation group（according to severity,all cases were divided into mild preeclampsia group,moderate group of preeclampsia and eclampsia group）,30 cases of normal maternal as a control group.Placental end of umbilical venous blood was drawn after the placenta was delivered.After separation of serum,serum levels of TNF-α were measured by ELISA.Results Umbilical vein serum levels of TNF-α in the observation group[（60.69±0.45） ng/L] were significantly higher than that in the normal group[（14.05±0.53） ng/L]（P0.05）.Umbilical vein serum levels of TNF-α was significantly difference in observation group between the various sub-groups and increased with exacerbations.Conclusion Pregnancy induced hypertension can cause maternal cord blood TNF-α and other harmful factors increase.

关 键 词：妊娠期高血压 脐静脉 肿瘤坏死因子 

分 类 号：R714.252[医药卫生—妇产科学]