2006-2010年铜绿假单胞菌的耐药性分析  

Drug resistance of Pseudomonas aeruginosafrom 2006 to 2010

作　　者：姜梅杰[1] 孙启英[1] 刘广丽[1] 

机构地区：[1]泰安市中心医院检验科,山东泰安271000

出　　处：《中华医院感染学杂志》2012年第8期1703-1704,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解医院铜绿假单胞菌的耐药性变迁,为临床合理使用抗菌药物及控制医院感染提供依据。方法对2006-2010年临床分离的1966株铜绿假单胞菌,用纸片扩散法检测其对亚胺培南等13种抗菌药物的耐药率。结果收集的1966株铜绿假单胞菌中,铜绿假单胞菌对阿米卡星、头孢他啶、头孢哌酮/舒巴坦的耐药率均<40.0%,分别为30.2%、30.4%、35.9%,对左氧氟沙星、亚胺培南的耐药率均>60.0%,分别为61.9%、63.1%,泛耐药铜绿假单胞菌呈逐年增加趋势。结论医院临床分离的铜绿假单胞菌耐药率高,临床应根据耐药特点合理选用抗菌药物,预防耐药菌在医院的暴发流行。OBJECTIVE To investigate the change of drug resistance of Pseudomonas aeruginosa（PAE） so as to provide evidence for the clinical application of antibiotics and the control of nosocomial infection.METHODS A total of 1966 stains of P.aeruginosa isolated from 2006 to 2010 were collected.Drug resistance to 13 antibiotics including imipenem was detected by disk diffusion method.RESULTS Of the 1966 strains of PAE gathered,the resistance rates to amikacin,ceftazidime,cefoperazone/sulbactam were less than 40.0%,which were 30.2%,30.4%,and 35.9%,respectively;those to levofloxacin and imipenem were higher than 60.0%,which were 61.9% and 63.1%,respectively.Pan-drug resistant Pseudomonas aeruginosa isolates have been increasing year by year.CONCLUSION The drug resistance rate of clinical isolates of P.aeruginosa is high.In order to prevent the outbreak and prevalence of the resistant strains,antibiotics should be chosen according to drug susceptibility test results in the clinical practice.

关 键 词：医院感染 铜绿假单胞菌 耐药性 

分 类 号：R378.996[医药卫生—病原生物学]