中药复方双秦眼用凝胶体外释药性能  

In vitro Releasing Property of Shuangqin Eye Gel

作　　者：刘树扬[1] 冯伟红[2] 杜茂波[2] 梁丽娜[3] 葛克亚[1] 刘淑芝[2] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]中国中医科学院中药研究所,北京100700 [3]中国中医科学院眼科医院,北京100040

出　　处：《中国实验方剂学杂志》2012年第8期9-11,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制科技专项(20092X09301-005)

摘　　要：目的:研究双秦眼用凝胶体外释放特性。方法:以秦皮甲素为指标,采用高效液相法进行含量测定;采用改良的Franz扩散池法,以半透膜为释放膜,研究双秦眼用凝胶的体外释放特性。结果:双秦眼用凝胶中秦皮甲素的释放以一级模型拟合较好,拟合方程Y=-1.258 8 X-0.816 2(r=0.999 2)。结论:双秦眼用凝胶释放为非Fick扩散。Objective：To study on in vivo releasing characteristics of Shuangqin eye gel.Method： The content of aesculin was determined by HPLC,which was used as index;Modified Franz diffusion cell method was applied to investigate in vitro release characteristics of Shuangqin eye gel with semi-permeable membrane as a barrier.Result： Aesculin in Shuangqin eye gel released fitted well with first order model,fitting equation of it：Y=-1.258 8 X-0.816 2（r=0.999 2）.Conclusion： Release of Shuangqin eye gel was non-Fick diffusion.

关 键 词：双秦眼用凝胶 释药性能 高效液相色谱法 FRANZ扩散池 秦皮甲素 

分 类 号：R283.6[医药卫生—中药学]